Alotiby Amna A
Department of Hematology and Immunology, Faculty of Medicine Umm Al-Qura University, Makkah, Saudi Arabia.
Front Pediatr. 2023 Feb 16;11:1086999. doi: 10.3389/fped.2023.1086999. eCollection 2023.
Breast milk is rich in nutrients and immunological factors capable of protecting infants against various immunological diseases and disorders. The current systematic review has been framed with the objective of studying the role of breastfeeding as a protective factor against the development of immune-mediated diseases.
The database and website searches were performed using PubMed, PubMed Central, Nature, Springer, Nature, Web of Science, and Elsevier. The studies were scrutinized based on the nature of participants and the nature of disease considered. The search was restricted to infants with immune-mediated diseases such as diabetes mellitus, allergic conditions, diarrhoea, and rheumatoid arthritis.
We have included 28 studies, out of which seven deal with diabetes mellitus, two rheumatoid arthritis, five studies about Celiac Disease, twelve studies about allergic/ asthma/wheezing conditions and one study on each of the following diseases: neonatal lupus erythematosus and colitis.
Based on our analysis, breastfeeding in association with the considered diseases was found to be positive. Breastfeeding is involved as protective factor against various diseases. The role of breastfeeding in the prevention of diabetes mellitus has been found to be significantly higher than for other diseases.
母乳富含营养物质和免疫因子，能够保护婴儿抵御各种免疫性疾病和紊乱。本次系统综述旨在研究母乳喂养作为免疫介导疾病发展的保护因素所起的作用。
通过PubMed、PubMed Central、Nature、Springer、Nature、Web of Science和Elsevier进行数据库和网站搜索。根据参与者的性质和所考虑疾病的性质对研究进行审查。搜索仅限于患有免疫介导疾病的婴儿，如糖尿病、过敏症、腹泻和类风湿性关节炎。
我们纳入了28项研究，其中7项涉及糖尿病，2项涉及类风湿性关节炎，5项关于乳糜泻，12项关于过敏/哮喘/喘息病症，以及以下每种疾病各1项研究：新生儿红斑狼疮和结肠炎。
基于我们的分析，发现母乳喂养与所考虑的疾病之间呈正向关联。母乳喂养作为抵御各种疾病的保护因素发挥作用。已发现母乳喂养在预防糖尿病方面的作用显著高于其他疾病。
