Medical University of Warsaw Poland, Clinic for Gynecological Endocrinology, Poland.
Invicta Infertility Center, Warsaw, Poland.
Biomed Res Int. 2020 Mar 4;2020:4092470. doi: 10.1155/2020/4092470. eCollection 2020.
Several studies have reported the association between polycystic ovary syndrome (PCOS) and low-grade chronic inflammation to be of uncertain cause: obesity, insulin resistance, or PCOS itself. The aim of the study was to investigate the WBC (white blood cell) count and CRP (C-reactive protein) concentration in women with PCOS and to determine the factors that affect their concentration. The study included 200 women aged 18-40 with PCOS and 105 healthy women as the control group, recruited in the Department of Gynaecological Endocrinology of Medical University in Warsaw from 2016 to 2018. Each patient underwent clinical, biochemical, and ultrasonographic assessments. WBC and CRP were significantly higher in the PCOS group ( = -2,353, = 0,019 and = -2,453, = 0,014). WBC positively correlated with serum insulin at 0, 60, and 120 min during the oral glucose tolerance test (INS0: = 0,221, = 0,001; INS1: = 0,194, = 0,003; INS2: = 0,022, = 0,001), testosterone ( = 0,130, = 0,046), androstenedione ( = 0,212, = 0,001), and DHEAS ( = 0,178, = 0,006) and negatively correlated with progesterone ( = -0,204, = 0,002), estradiol ( = -0,140, = 0,032), and SHBG ( = -0,308, < 0,001). CRP positively correlated with insulin concentration in 0, 60, and 120 min during the oral glucose tolerance test (INS0: = 0,343, < 0,001; INS1: = 0,276, = 0,001; INS2: = 0,320, < 001) and negatively correlated with progesterone ( = -0,194, = 0,030) and SHBG (-0,244, = 0,005). We also estimated positive correlation between BMI and serum CRP and WBC concentration. Multiple linear regression analysis showed that CRP values are positively associated with BMI (beta = 0,374, < 0,001) and insulin level (INS1) (beta = 0,282, = 0,004); and WBC results are negatively associated with SHGB (beta = -0,284, < 0,001) but positively associated with testosterone (beta = 0,163, = 0,024) and BMI (beta = 0,157, = 0,047). PCOS is associated with increased WBC and CRP concentrations. The main predicting factors of increased CRP are BMI and insulin resistance, but there is also a relationship between WBC count in PCOS and androgen concentration itself so that inflammation may be mediated not only through adiposity but also through increased androgen concentration.
多囊卵巢综合征（PCOS）与低度慢性炎症之间的关联被认为其病因不确定：肥胖、胰岛素抵抗或 PCOS 本身。本研究旨在调查 PCOS 患者的白细胞（WBC）计数和 C 反应蛋白（CRP）浓度，并确定影响其浓度的因素。该研究纳入了 2016 年至 2018 年期间在华沙医科大学妇科内分泌科招募的 200 名年龄在 18-40 岁的 PCOS 患者和 105 名健康女性作为对照组。每位患者均接受了临床、生化和超声评估。PCOS 组的 WBC 和 CRP 显著升高（= -2,353，= 0.019 和 = -2,453，= 0.014）。WBC 与口服葡萄糖耐量试验（OGTT）0、60 和 120 分钟时的血清胰岛素呈正相关（INS0：= 0.221，= 0.001；INS1：= 0.194，= 0.003；INS2：= 0.022，= 0.001）、睾酮（= 0.130，= 0.046）、雄烯二酮（= 0.212，= 0.001）和脱氢表雄酮（= 0.178，= 0.006），与孕酮（= -0.204，= 0.002）、雌二醇（= -0.140，= 0.032）和 SHBG（= -0.308，<0.001）呈负相关。CRP 与 OGTT 0、60 和 120 分钟时的胰岛素浓度呈正相关（INS0：= 0.343，<0.001；INS1：= 0.276，= 0.001；INS2：= 0.320，<0.001），与孕酮（= -0.194，= 0.030）和 SHBG（-0.244，= 0.005）呈负相关。我们还估计了 BMI 和血清 CRP 与 WBC 浓度之间的正相关。多元线性回归分析显示，CRP 值与 BMI（β=0.374，<0.001）和胰岛素水平（INS1）（β=0.282，=0.004）呈正相关；WBC 结果与 SHBG（β= -0.284，<0.001）呈负相关，但与睾酮（β=0.163，=0.024）和 BMI（β=0.157，=0.047）呈正相关。PCOS 与 WBC 和 CRP 浓度升高有关。CRP 升高的主要预测因素是 BMI 和胰岛素抵抗，但 PCOS 患者的白细胞计数与雄激素浓度之间也存在关系，因此炎症可能不仅通过肥胖，还可能通过增加雄激素浓度来介导。
