一种抗冻蛋白的抗毒力特性。
Antivirulence properties of an antifreeze protein.
作者信息
Heisig Martin, Abraham Nabil M, Liu Lei, Neelakanta Girish, Mattessich Sarah, Sultana Hameeda, Shang Zhengling, Ansari Juliana M, Killiam Charlotte, Walker Wendy, Cooley Lynn, Flavell Richard A, Agaisse Herve, Fikrig Erol
机构信息
Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520, USA.
Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
出版信息
Cell Rep. 2014 Oct 23;9(2):417-24. doi: 10.1016/j.celrep.2014.09.034. Epub 2014 Oct 16.
As microbial drug-resistance increases, there is a critical need for new classes of compounds to combat infectious diseases. The Ixodes scapularis tick antifreeze glycoprotein, IAFGP, functions as an antivirulence agent against diverse bacteria, including methicillin-resistant Staphylococcus aureus. Recombinant IAFGP and a peptide, P1, derived from this protein bind to microbes and alter biofilm formation. Transgenic iafgp-expressing flies and mice challenged with bacteria, as well as wild-type animals administered P1, were resistant to infection, septic shock, or biofilm development on implanted catheter tubing. These data show that an antifreeze protein facilitates host control of bacterial infections and suggest therapeutic strategies for countering pathogens.
随着微生物耐药性的增加，迫切需要新型化合物来对抗传染病。肩突硬蜱抗冻糖蛋白（IAFGP）可作为一种抗毒力剂，对抗包括耐甲氧西林金黄色葡萄球菌在内的多种细菌。重组IAFGP及其衍生肽P1可与微生物结合并改变生物膜的形成。用细菌攻击的转基因表达iafgp的果蝇和小鼠，以及给予P1的野生型动物，对植入导管上的感染、败血症休克或生物膜形成具有抗性。这些数据表明，一种抗冻蛋白有助于宿主控制细菌感染，并提出了对抗病原体的治疗策略。
Zotero 插件