Appiah Clara, Chen Shitian, Pori Afia Ibnat, Retyunskiy Vladimir, Tzeng Chimeng, Zhao Ye
School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, China.
School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
Front Pharmacol. 2024 Feb 16;15:1359261. doi: 10.3389/fphar.2024.1359261. eCollection 2024.
Antimicrobial peptides (AMPs) are widely distributed throughout the biosphere and represent a class of conserved peptide molecules with intrinsic antimicrobial properties. Their broad-spectrum antimicrobial activity and low risk to induce resistance have led to increased interest in AMPs as potential alternatives to traditional antibiotics. Among the AMPs, alloferon has been addressed due to its immunomodulatory properties that augment both innate and adaptive immune responses against various pathogens. Alloferon and its analogues have demonstrated pharmaceutical potential through their ability to enhance Natural Killer (NK) cell cytotoxicity and stimulate interferon (IFN) synthesis in both mouse and human models. Additionally, they have shown promise in augmenting antiviral and antitumor activities in mice. In this article, we provide a comprehensive review of the biological effects of alloferon and its analogues, incorporating our own research findings as well. These insights may contribute to a deeper understanding of the therapeutic potential of these novel AMPs.
抗菌肽（AMPs）广泛分布于整个生物圈，是一类具有固有抗菌特性的保守肽分子。它们的广谱抗菌活性以及诱导耐药性的低风险，使得人们对AMPs作为传统抗生素的潜在替代品越来越感兴趣。在抗菌肽中，阿洛干扰素因其免疫调节特性而受到关注，该特性可增强针对各种病原体的先天性和适应性免疫反应。在小鼠和人类模型中，阿洛干扰素及其类似物通过增强自然杀伤（NK）细胞的细胞毒性和刺激干扰素（IFN）合成，展现出了药物潜力。此外，它们在增强小鼠的抗病毒和抗肿瘤活性方面也显示出了前景。在本文中，我们结合自己的研究结果，对抗菌肽及其类似物的生物学效应进行了全面综述。这些见解可能有助于更深入地了解这些新型抗菌肽的治疗潜力。
