Rose B I
Infertility Solutions, P. C., 1275 South Cedar Crest Boulevard, Allentown, PA 18103, USA. Department of Obstetrics and Gynecology, St. Luke's University Health Network, 801 Ostrum Street, Bethlehem, PA 18015, USA.
Facts Views Vis Obgyn. 2014;6(3):150-5.
To compare the pregnancy rates with two different methods of priming for in vitro maturation cycles (IVM). Cycles using letrozole together with hCG were compared to cycles using FSH together with hCG in 75 cycles in patients being treated for infertility by IVM.
Retrospective cohort non-inferiority trial Results: Using letrozole for priming was found to not be inferior to using FSH for priming cycles. The live birth rate per transfer was 31.6% in letrozole primed cycles compared to 20.8% in FSH primed cycles (not significant). However, FSH priming produced more oocytes that were mature on the day of retrieval (p = 0.004) and also resulted in more high quality embryos than did letrozole priming (p = 0.004).
Letrozole may be used for priming in IVM cycles in which the clinician views the characteristics of letrozole as more desirable than FSH.
比较两种不同的体外成熟周期（IVM）启动方法的妊娠率。在75个接受IVM治疗不孕症的患者周期中，将使用来曲唑联合人绒毛膜促性腺激素（hCG）的周期与使用促卵泡激素（FSH）联合hCG的周期进行比较。
回顾性队列非劣效性试验结果：发现使用来曲唑启动并不劣于使用FSH启动周期。来曲唑启动周期的每次移植活产率为31.6%，而FSH启动周期为20.8%（无显著差异）。然而，FSH启动产生的在取卵当天成熟的卵母细胞更多（p = 0.004），并且与来曲唑启动相比，还产生了更多高质量的胚胎（p = 0.004）。
在临床医生认为来曲唑的特性比FSH更可取的IVM周期中，来曲唑可用于启动。
