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含5-氯-2-甲氧基苯基的新型1,3,4-恶二唑的合成及体外抗菌活性评价

Synthesis and In Vitro Antimicrobial Evaluation of New 1,3,4-Oxadiazoles Bearing 5-Chloro-2-methoxyphenyl Moiety.

作者信息

Prasanna Kumar Basavapatna N, Mohana Kikkeri N, Mallesha Lingappa, Harish Kikkeri P

机构信息

Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India.

The Postgraduate Department of Chemistry, JSS College of Arts, Commerce and Science, Ooty Road, Mysore 25, India.

出版信息

Int J Med Chem. 2013;2013:725673. doi: 10.1155/2013/725673. Epub 2013 Mar 31.

DOI:10.1155/2013/725673
PMID:25374693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4207447/
Abstract

A series of new 1,3,4-oxadiazole derivatives, 4(a-h), containing 5-chloro-2-methoxy benzohydrazide moiety were synthesized by the reaction of 5-chloro-2-methoxybenzoate with different aromatic carboxylic acids. These newly synthesized compounds were characterized by FT-IR, (1)H NMR, mass spectra, and also by elemental analysis. All the newly synthesized compounds were screened for their antibacterial and antifungal activities. Antimicrobial studies revealed that compounds 4c, 4f, and 4g showed significant activity against tested strains.

摘要

通过5-氯-2-甲氧基苯甲酸酯与不同的芳香族羧酸反应，合成了一系列含有5-氯-2-甲氧基苯甲酰肼部分的新型1,3,4-恶二唑衍生物4（a - h）。这些新合成的化合物通过傅里叶变换红外光谱（FT-IR）、核磁共振氢谱（¹H NMR）、质谱以及元素分析进行了表征。对所有新合成的化合物进行了抗菌和抗真菌活性筛选。抗菌研究表明，化合物4c、4f和4g对测试菌株显示出显著活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e86/4207447/de1bb666eda4/IJMC2013-725673.sch.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e86/4207447/de1bb666eda4/IJMC2013-725673.sch.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e86/4207447/de1bb666eda4/IJMC2013-725673.sch.001.jpg

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