Kalaria R N, Stockmeier C A, Harik S I
Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Neurosci Lett. 1989 Feb 13;97(1-2):203-8. doi: 10.1016/0304-3940(89)90164-x.
Noradrenergic fibers from the locus ceruleus were identified in close proximity to brain microvessels, and adrenoceptors exist in isolated brain capillaries. Yet, proof of innervation of brain microvessels by locus ceruleus remains elusive. We now demonstrate increased density of beta-adrenoceptors by pindolol binding in microvessels isolated from the norepinephrine-depleted cerebrum two weeks after locus ceruleus lesion or reserpine treatment. This finding of 'denervation supersensitivity' in brain microvessels implies that their adrenoceptors respond to norepinephrine from the locus ceruleus, and strongly suggests that the locus ceruleus innervates brain microvessels. These results may have important implications because blood-brain barrier dysfunction may be a factor in the pathophysiology of Alzheimer dementia and Parkinson disease, which are associated with locus ceruleus degeneration.
已确定来自蓝斑核的去甲肾上腺素能纤维紧邻脑微血管，且分离出的脑毛细血管中存在肾上腺素能受体。然而，蓝斑核对脑微血管的神经支配证据仍不明确。我们现在证明，在蓝斑核损伤或利血平治疗两周后，从去甲肾上腺素耗竭的大脑中分离出的微血管中，通过吲哚洛尔结合显示β-肾上腺素能受体密度增加。脑微血管中这种“去神经超敏反应”的发现意味着其肾上腺素能受体对来自蓝斑核的去甲肾上腺素作出反应，并强烈表明蓝斑核对脑微血管有神经支配。这些结果可能具有重要意义，因为血脑屏障功能障碍可能是与蓝斑核变性相关的阿尔茨海默病和帕金森病病理生理学中的一个因素。
