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肾移植后 HLA 抗体监测的临床意义。

Clinical relevance of HLA antibody monitoring after kidney transplantation.

机构信息

Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany.

Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany.

出版信息

J Immunol Res. 2014;2014:845040. doi: 10.1155/2014/845040. Epub 2014 Oct 13.

DOI:10.1155/2014/845040
PMID:25374891
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4211317/
Abstract

In kidney transplantation, antibody-mediated allograft injury caused by donor HLA-specific antibodies (DSA) has recently been identified as one of the major causes of late graft loss. This paper gives a brief overview on the impact of DSA development on graft outcome in organ transplantation with a focus on risk factors for de novo alloantibody induction and recently published guidelines for monitoring of DSA during the posttransplant phase.

摘要

在肾移植中，由供体 HLA 特异性抗体（DSA）引起的抗体介导的同种异体移植物损伤最近已被确定为晚期移植物丢失的主要原因之一。本文简要概述了 DSA 发展对器官移植中移植物结局的影响，重点介绍了新发性同种异体抗体诱导的危险因素和最近发布的移植后阶段 DSA 监测指南。

相似文献

1
Clinical relevance of HLA antibody monitoring after kidney transplantation.肾移植后 HLA 抗体监测的临床意义。
J Immunol Res. 2014;2014:845040. doi: 10.1155/2014/845040. Epub 2014 Oct 13.
2
Association of Kidney Graft Loss With De Novo Produced Donor-Specific and Non-Donor-Specific HLA Antibodies Detected by Single Antigen Testing.通过单抗原检测发现的新发供者特异性和非供者特异性HLA抗体与肾移植丢失的关联
Transplantation. 2015 Sep;99(9):1976-80. doi: 10.1097/TP.0000000000000672.
3
Targeted monitoring of donor-specific HLA antibodies following renal transplantation.肾移植后供体特异性HLA抗体的靶向监测。
Clin Transpl. 2011:395-400.
4
Incidences of preformed and de novo donor-specific HLA antibodies and their clinicohistological correlates in the early course of kidney transplantation.肾移植早期预先形成的和新生的供者特异性HLA抗体的发生率及其临床组织学相关性
Clin Transpl. 2012:247-56.
5
Relevance of different antibody detection methods for the prediction of antibody-mediated rejection and deceased-donor kidney allograft survival.不同抗体检测方法对预测抗体介导的排斥反应及死亡供者肾移植受者生存率的相关性
Hum Immunol. 2009 Aug;70(8):589-94. doi: 10.1016/j.humimm.2009.04.018. Epub 2009 Apr 15.
6
Impact of alloantibody strength in crossmatch negative DSA positive kidney transplantation.交叉配型阴性、直接抗球蛋白试验阳性的肾移植中同种抗体强度的影响。
Clin Biochem. 2013 Oct;46(15):1389-93. doi: 10.1016/j.clinbiochem.2013.05.053. Epub 2013 May 29.
7
Impact of de novo donor-specific HLA antibodies detected by Luminex solid-phase assay after transplantation in a group of 88 consecutive living-donor renal transplantations.在 88 例连续活体供肾移植受者中，应用 Luminex 固相法检测到移植后新出现的供者特异性 HLA 抗体的影响。
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De novo donor specific antibodies and patient outcomes in renal transplantation.肾移植中新生供者特异性抗体与患者预后
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BMC Mol Cell Biol. 2025 Jul 16;26(1):22. doi: 10.1186/s12860-025-00549-5.
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Expanding role of antibodies in kidney transplantation.抗体在肾移植中不断扩大的作用。
World J Transplant. 2025 Mar 18;15(1):99220. doi: 10.5500/wjt.v15.i1.99220.
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De Novo Donor-Specific Antibodies after Heart Transplantation: A Comprehensive Guide for Clinicians.心脏移植术后新发供者特异性抗体：临床医生综合指南
J Clin Med. 2023 Dec 2;12(23):7474. doi: 10.3390/jcm12237474.
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Novel insights in the clinical management of hyperimmune patients before and after transplantation.移植前后超免疫患者临床管理的新见解。
Curr Res Immunol. 2023 Jan 23;4:100056. doi: 10.1016/j.crimmu.2023.100056. eCollection 2023.
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Retrospective Study from a Single Center in Romania of 347 Renal Transplant Patients Treated with Tacrolimus, Mycophenolate, and Steroids to Evaluate the Association Between Anti-HLA Antibodies and 5-Year Graft Survival.罗马尼亚单中心对347例接受他克莫司、霉酚酸酯和类固醇治疗的肾移植患者进行的回顾性研究，以评估抗HLA抗体与5年移植物存活率之间的关联。
Ann Transplant. 2022 Aug 12;27:e937267. doi: 10.12659/AOT.937267.
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Approaches for Controlling Antibody-Mediated Allograft Rejection Through Targeting B Cells.通过靶向 B 细胞控制抗体介导的同种异体移植排斥反应的方法。
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Donor Specific Antibody and Long-Term Outcome After Liver Transplantation: A Systematic Review and Meta-Analysis.供体特异性抗体与肝移植后长期结局：系统评价和荟萃分析。
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本文引用的文献

1
Banff 2013 meeting report: inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions.班夫 2013 年会议报告：包含 C4d 阴性抗体介导的排斥反应和抗体相关的动脉病变。
Am J Transplant. 2014 Feb;14(2):272-83. doi: 10.1111/ajt.12590.
2
The 2013 International Society for Heart and Lung Transplantation Working Formulation for the standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation.2013 年国际心肺移植学会关于心脏移植中抗体介导排斥反应病理诊断命名标准化的工作方案。
J Heart Lung Transplant. 2013 Dec;32(12):1147-62. doi: 10.1016/j.healun.2013.08.011.
3
Complement-binding anti-HLA antibodies and kidney-allograft survival.补体结合抗 HLA 抗体与肾移植存活。
N Engl J Med. 2013 Sep 26;369(13):1215-26. doi: 10.1056/NEJMoa1302506.
4
Influence of test technique on sensitization status of patients on the kidney transplant waiting list.检测技术对肾移植等待名单中患者致敏状态的影响。
Am J Transplant. 2013 Aug;13(8):2075-82. doi: 10.1111/ajt.12332. Epub 2013 Jul 10.
5
Posttransplant monitoring of de novo human leukocyte antigen donor-specific antibodies in kidney transplantation.移植后新产生的人类白细胞抗原供体特异性抗体在肾移植中的监测。
Curr Opin Organ Transplant. 2013 Aug;18(4):470-7. doi: 10.1097/MOT.0b013e3283626149.
6
The role of immunoglobulin-G subclasses and C1q in de novo HLA-DQ donor-specific antibody kidney transplantation outcomes.免疫球蛋白-G 亚类和 C1q 在 HLA-DQ 供体特异性抗体肾移植结局中的作用。
Transplantation. 2013 May 15;95(9):1113-9. doi: 10.1097/TP.0b013e3182888db6.
7
Incidence and impact of de novo donor-specific alloantibody in primary renal allografts.原发性肾移植中供体特异性同种异体抗体的发生率和影响。
Transplantation. 2013 Feb 15;95(3):410-7. doi: 10.1097/TP.0b013e31827d62e3.
8
Living donor kidney transplantation in patients with donor-specific HLA antibodies enabled by anti-CD20 therapy and peritransplant apheresis.通过抗CD20治疗和移植期血液分离术实现的具有供体特异性HLA抗体患者的活体供肾移植。
Atheroscler Suppl. 2013 Jan;14(1):199-202. doi: 10.1016/j.atherosclerosissup.2012.10.030.
9
Consensus guidelines on the testing and clinical management issues associated with HLA and non-HLA antibodies in transplantation.移植中与 HLA 和非 HLA 抗体相关的检测和临床管理问题的共识指南。
Transplantation. 2013 Jan 15;95(1):19-47. doi: 10.1097/TP.0b013e31827a19cc.
10
Posttransplant de novo donor-specific hla antibodies identify pediatric kidney recipients at risk for late antibody-mediated rejection.移植后新出现的供体特异性 HLA 抗体可识别发生晚期抗体介导排斥反应风险的儿科肾移植受者。
Am J Transplant. 2012 Dec;12(12):3355-62. doi: 10.1111/j.1600-6143.2012.04251.x. Epub 2012 Sep 7.