Swirski F K
Filip K. Swirski, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston,, MA 02114, USA, E-mail:
Hamostaseologie. 2015;35(1):34-6. doi: 10.5482/HAMO-14-09-0045. Epub 2014 Nov 6.
Shortly after myocardial infarction, various circulating leukocyte subsets accumulate in the heart. Leukocyte recruitment is highly coordinated and relies on cell production in the bone marrow, mobilization to the blood, and chemokine-mediated infiltration to the destination tissue. Neutrophils, which are phagocytic and inflammatory, are among the first leukocytes to accumulate in large numbers. Within a day, neutrophils disappear and are replaced by a subset of monocytes that further contribute to inflammation and phagocytosis. After a few days, monocyte-derived reparative macrophages accrue, quell inflammation, and foster angiogenesis and tissue remodelling. Studies suggest a well-balanced response comprising these three waves is essential to optimal infarct healing.
心肌梗死后不久，各种循环白细胞亚群会在心脏中积聚。白细胞的募集是高度协调的，依赖于骨髓中的细胞生成、向血液中的动员以及趋化因子介导的向目标组织的浸润。具有吞噬和炎症作用的中性粒细胞是最早大量积聚的白细胞之一。在一天之内，中性粒细胞消失，并被一部分单核细胞取代，这些单核细胞会进一步加剧炎症和吞噬作用。几天后，单核细胞衍生的修复性巨噬细胞积聚，平息炎症，并促进血管生成和组织重塑。研究表明，由这三个阶段组成的平衡良好的反应对于实现最佳梗死愈合至关重要。
