Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium; Department of Internal Medicine, Ghent University, Ghent, Belgium.
Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium; Department of Internal Medicine, Ghent University, Ghent, Belgium; Department of Pulmonary Medicine, ErasmusMC, Rotterdam, The Netherlands.
Cell Immunol. 2018 Aug;330:105-113. doi: 10.1016/j.cellimm.2018.03.011. Epub 2018 Apr 5.
Heart disease is the major cause of death and it is broadly recognized that the immune system plays a central role in healthy and injured heart. Here, we focus on the contribution of various subsets of mononuclear phagocytes in the cardiac system. Macrophages and dendritic cells reside in the healthy myocardium to fulfill homeostatic functions and rapidly increase in numbers in diseases like myocardial ischemia and myocarditis to contribute to disease or resolve it. Recent experiments have revealed the extraordinary heterogeneity of cardiac mononuclear phagocytes that differ in origin, lifespan, phenotype and function. Although many studies described cardiac phagocytes in the mouse, subsets of cardiac mononuclear phagocytes can also be broadly found in the human heart, opening up the potential of selective targeting of these cells in a therapeutic setting. Before this goal can be achieved we need better understanding not only of the detrimental but also beneficial functions of these highly diverse cells in the heart.
心脏病是主要的死亡原因，人们普遍认为免疫系统在健康和受损的心脏中起着核心作用。在这里，我们专注于单核吞噬细胞的各种亚群在心脏系统中的贡献。巨噬细胞和树突状细胞存在于健康的心肌中，以发挥其稳态功能，并在心肌缺血和心肌炎等疾病中迅速增加数量，以促进疾病的发展或使其消退。最近的实验揭示了心脏单核吞噬细胞的非凡异质性，它们在起源、寿命、表型和功能上存在差异。尽管许多研究在小鼠中描述了心脏吞噬细胞，但心脏单核吞噬细胞的亚群也可以在人类心脏中广泛发现，为在治疗环境中选择性靶向这些细胞开辟了可能性。在实现这一目标之前，我们不仅需要更好地了解这些高度多样化的细胞在心脏中的有害功能，还需要了解它们的有益功能。
