Haemostasis Thrombosis and Vascular Biology Unit, University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham B18 7QH, UK.
Cardiovasc Res. 2010 Mar 1;85(4):649-60. doi: 10.1093/cvr/cvp327. Epub 2009 Oct 4.
Monocytes play an important role in immune defence, inflammation, and tissue remodelling. Nevertheless, the role of monocytes in cardiovascular disease is obscure. Indeed, monocytes infiltrate dysfunctional tissue and augment tissue damage and are actively involved in tissue regeneration and healing. In support of the latter, recent studies have provided data on the functional and structural plasticity of monocytes. Monocytes are also actively involved in processes associated with tissue regeneration such as angiogenesis and vasculogenesis, either by producing pro-angiogenic factors or even by evolving to structural components of the vascular wall. This review article provides an overview on whether monocytes represent deteriorating immune overreaction in heart failure (HF), or a desperate attempt for tissue repair or physiological compensation in the failing heart. Perhaps, it is time to reconsider our attitude towards monocytes and consider more 'monocyte activation' rather than 'monocyte suppression' as a potential therapeutic target in HF.
单核细胞在免疫防御、炎症和组织重塑中发挥着重要作用。然而，单核细胞在心血管疾病中的作用尚不清楚。事实上，单核细胞浸润功能失调的组织并加剧组织损伤，并积极参与组织再生和修复。最近的研究为单核细胞的功能和结构可塑性提供了数据，支持了后者的观点。单核细胞还积极参与与组织再生相关的过程，如血管生成和血管发生，它们可以通过产生促血管生成因子，甚至通过演变为血管壁的结构成分来实现这一点。本文综述了单核细胞是否代表心力衰竭（HF）中恶化的免疫过度反应，还是衰竭心脏进行组织修复或生理代偿的绝望尝试。也许，现在是重新考虑我们对单核细胞的态度的时候了，将更多地考虑“单核细胞激活”而不是“单核细胞抑制”作为 HF 的潜在治疗靶点。
