Breslow M F, Fankhauser M P, Potter R L, Meredith K E, Misiaszek J, Hope D G
Department of Psychiatry, University of Arizona Health Sciences Center, Tucson 85724.
Am J Psychiatry. 1989 Mar;146(3):353-6. doi: 10.1176/ajp.146.3.353.
All effective pharmacologic agents used to treat panic disorder augment gamma-aminobutyric acid (GABA) transmission. Anxiolytics and antidepressants that lack GABA activity are not effective in panic disorder. To test the hypothesis that GABA activity is a component of antipanic drug efficacy, the authors treated nine medication-free panic disorder subjects with oral baclofen (30 mg/day for 4 weeks) in a double-blind, placebo-controlled crossover trial. Baclofen, a selective GABA agonist, was significantly more effective than placebo in reducing the number of panic attacks and scores on the Hamilton anxiety scale, Zung scale, and Katz-R nervousness subscale. The authors discuss possible mechanisms of antipanic drug efficacy.
所有用于治疗惊恐障碍的有效药物都能增强γ-氨基丁酸（GABA）的传递。缺乏GABA活性的抗焦虑药和抗抑郁药对惊恐障碍无效。为了验证GABA活性是抗惊恐药物疗效的一个组成部分这一假设，作者在一项双盲、安慰剂对照的交叉试验中，对9名未服用药物的惊恐障碍患者口服巴氯芬（30毫克/天，共4周）进行治疗。巴氯芬是一种选择性GABA激动剂，在减少惊恐发作次数以及汉密尔顿焦虑量表、zung量表和卡茨-R紧张分量表的得分方面，显著优于安慰剂。作者讨论了抗惊恐药物疗效的可能机制。
