一种用于一氧化碳前药的点击释放方法。
A click-and-release approach to CO prodrugs.
作者信息
Wang Danzhu, Viennois Emilie, Ji Kaili, Damera Krishna, Draganov Alexander, Zheng Yueqing, Dai Chaofeng, Merlin Didier, Wang Binghe
机构信息
Department of Chemistry, Georgia State University, Atlanta, 30303-3083, Georgia.
出版信息
Chem Commun (Camb). 2014 Dec 28;50(100):15890-3. doi: 10.1039/c4cc07748b.
Carbon monoxide belongs to the family of signaling molecules and has been shown to possess therapeutic effects. Similar to NO, safe delivery of CO is a key issue in developing CO-based therapeutics. Herein we report a "click and release" CO-prodrug approach, which allows the release of CO under physiological conditions without the need for light irradiation. The system releases CO in a triggered and controllable manner and possesses the potential of tunable release rates.
一氧化碳属于信号分子家族，已被证明具有治疗作用。与一氧化氮类似，一氧化碳的安全递送是开发基于一氧化碳的疗法的关键问题。在此，我们报道了一种“点击释放”一氧化碳前药方法，该方法可在生理条件下释放一氧化碳，无需光照。该系统以触发和可控的方式释放一氧化碳，并具有可调释放速率的潜力。
Zotero 插件