Ji Xingyue, Ji Kaili, Chittavong Vayou, Yu Bingchen, Pan Zhixiang, Wang Binghe
Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University Atlanta, Georgia 30303, USA.
Chem Commun (Camb). 2017 Jul 20;53(59):8296-8299. doi: 10.1039/c7cc03832a.
One major challenge in the development of CO as a therapeutic agent is its controllable delivery in a pharmaceutically acceptable form. Herein, we describe for the first time a general chemical strategy to esterase-sensitive organic CO-prodrugs.
将一氧化碳作为治疗剂开发的一个主要挑战是如何以药学上可接受的形式进行可控递送。在此，我们首次描述了一种针对酯酶敏感型有机一氧化碳前药的通用化学策略。
