一种用于无金属一氧化碳前药的酯酶激活点击释放方法。
An esterase-activated click and release approach to metal-free CO-prodrugs.
作者信息
Ji Xingyue, Ji Kaili, Chittavong Vayou, Yu Bingchen, Pan Zhixiang, Wang Binghe
机构信息
Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University Atlanta, Georgia 30303, USA.
出版信息
Chem Commun (Camb). 2017 Jul 20;53(59):8296-8299. doi: 10.1039/c7cc03832a.
PMID:28685779
Abstract
One major challenge in the development of CO as a therapeutic agent is its controllable delivery in a pharmaceutically acceptable form. Herein, we describe for the first time a general chemical strategy to esterase-sensitive organic CO-prodrugs.
摘要
将一氧化碳作为治疗剂开发的一个主要挑战是如何以药学上可接受的形式进行可控递送。在此，我们首次描述了一种针对酯酶敏感型有机一氧化碳前药的通用化学策略。
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