Pan Zhixiang, Chittavong Vayou, Li Wei, Zhang Jun, Ji Kaili, Zhu Mengyuan, Ji Xingyue, Wang Binghe
Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, 30303, USA.
School of Pharmacy, Jining Medical University, Rizhao, Shandong, 276826, P. R. China.
Chemistry. 2017 Jul 21;23(41):9838-9845. doi: 10.1002/chem.201700936. Epub 2017 Jul 4.
Carbon monoxide (CO) is an endogenously produced gasotransmitter in mammals, and may have signaling roles in bacteria as well. It has many recognized therapeutic effects. A significant challenge in this field is the development of pharmaceutically acceptable forms of CO delivery with controllable and tunable release rates. Herein, the structure-release rate studies of the first class of organic CO prodrugs that release CO in aqueous solution at neutral pH is described.
一氧化碳（CO）是哺乳动物体内内源性产生的气体递质，在细菌中可能也具有信号传导作用。它具有许多公认的治疗作用。该领域的一个重大挑战是开发具有可控和可调释放速率的药学上可接受的CO递送形式。本文描述了第一类在中性pH值的水溶液中释放CO的有机CO前药的结构-释放速率研究。
