具有可调节和可预测释放速率的pH敏感无金属一氧化碳前药。
pH-Sensitive metal-free carbon monoxide prodrugs with tunable and predictable release rates.
作者信息
Ji Xingyue, De La Cruz Ladie Kimberly C, Pan Zhixiang, Chittavong Vayou, Wang Binghe
机构信息
Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University Atlanta, Georgia 30303, USA.
出版信息
Chem Commun (Camb). 2017 Aug 24;53(69):9628-9631. doi: 10.1039/c7cc04866a.
Carbon monoxide prodrugs with triggered release profiles are highly desirable for targeted CO delivery to minimize their untoward side-effects. Herein, we describe a series of pH-sensitive metal-free CO prodrugs which are stable under acidic conditions and yet begin to release CO in response to increases in pH with tunable and predictable release rates.
具有触发释放特性的一氧化碳前药对于将一氧化碳靶向递送至特定部位以尽量减少其不良副作用而言是非常理想的。在此，我们描述了一系列对pH敏感的无金属一氧化碳前药，它们在酸性条件下稳定，但随着pH值升高会开始释放一氧化碳，释放速率可调且可预测。
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