Kaye Walter H, Wierenga Christina E, Knatz Stephanie, Liang June, Boutelle Kerri, Hill Laura, Eisler Ivan
Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
Eur Eat Disord Rev. 2015 Jan;23(1):12-8. doi: 10.1002/erv.2330. Epub 2014 Nov 6.
Anorexia nervosa (AN) tends to be a chronic and deadly disorder with no proven treatments that reverse core symptoms in adults. New insight into neurobiological mechanisms that contribute to symptoms may support development of more effective interventions. We describe the development of a temperament-based treatment for AN on the basis of empirically supported models. It uses a systemized approach and takes into consideration an understanding of how neurobiological mechanisms are expressed through behaviour and personality and contribute to specific AN symptomatology. This model integrates the development of AN-focused constructive coping strategies with carer-focused strategies to manage temperament traits that contribute to AN symptomatology. This intervention is consistent with the recent Novel Interventions for Mental Disorders initiative mandating that treatment trials follow an experimental medicine approach by identifying underlying mechanisms that are directly targeted by the intervention to influence symptoms.
神经性厌食症（AN）往往是一种慢性致命疾病，目前尚无经证实的能逆转成人核心症状的治疗方法。对导致症状的神经生物学机制的新见解可能有助于开发更有效的干预措施。我们描述了一种基于气质的AN治疗方法的开发，该方法基于经验支持的模型。它采用系统化方法，并考虑如何通过行为和个性来表达神经生物学机制以及这些机制如何导致特定的AN症状。该模型将以AN为重点的建设性应对策略的发展与以照顾者为重点的策略相结合，以管理导致AN症状的气质特征。这种干预措施符合最近的精神障碍新干预措施倡议，该倡议要求治疗试验采用实验医学方法，即确定干预措施直接针对的潜在机制以影响症状。
