CX3CR1基因V249I多态性与肾移植术后移植肾功能延迟之间的关联。
Association between the CX3CR1 gene V249I polymorphism and delayed kidney allograft function.
作者信息
Dabrowska-Zamojcin Ewa, Dziedziejko Violetta, Safranow Krzysztof, Kurzawski Mateusz, Domanski Leszek, Pawlik Andrzej
机构信息
Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland.
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland.
出版信息
Transpl Immunol. 2015 Jun;32(3):172-4. doi: 10.1016/j.trim.2015.04.002. Epub 2015 Apr 18.
BACKGROUND
Fractalkine is a member of the chemokine family that acts as an adhesion molecule and as an extracellular chemoattractant promoting cellular migration. In this study, we analysed the association between the CX3CR1 gene V249I (rs3732379) SNP and renal allograft function.
METHODS
The study enrolled 270 Caucasian kidney allograft recipients. The following parameters were recorded in each case: the recipient's age and gender, delayed graft function (DGF) defined as the need for dialysis in the first 7 days after transplantation, occurrence and number of episodes of acute rejection (AR), and chronic allograft dysfunction (CAD).
RESULTS
Delayed graft function was diagnosed in 39.2% of individuals with the CC genotype, 22.7% with CT and 23.5% of those with the TT genotype. The differences were statistically significant (CC vs. TT+CT: OR = 2.17; 95% CI = 1.28-3.70, p = 0.0042). In multivariate analysis the CC genotype was an independent and significant predictor of higher risk of DGF. The distribution of genotypes and alleles of the CX3CR1 gene polymorphism among patients with and without AR as well as CAD did not differ significantly.
CONCLUSIONS
The results of this study suggest that the CX3CR1 gene V249I (rs3732379) SNP CC genotype is associated with increased risk of DGF.
背景
趋化因子是趋化因子家族的一员，它作为一种黏附分子和细胞外趋化因子，促进细胞迁移。在本研究中，我们分析了CX3CR1基因V249I（rs3732379）单核苷酸多态性与肾移植功能之间的关联。
方法
该研究纳入了270名白种人肾移植受者。记录了每个病例的以下参数：受者的年龄和性别、移植肾功能延迟（DGF），定义为移植后前7天内需要透析、急性排斥反应（AR）发作的发生率和次数，以及慢性移植肾功能障碍（CAD）。
结果
CC基因型个体中39.2%被诊断为移植肾功能延迟，CT基因型个体中为22.7%，TT基因型个体中为23.5%。差异具有统计学意义（CC与TT + CT比较：OR = 2.17；95% CI = 1.28 - 3.70，p = 0.0042）。在多变量分析中，CC基因型是移植肾功能延迟高风险的独立且显著的预测因素。CX3CR1基因多态性的基因型和等位基因在有或无急性排斥反应以及慢性移植肾功能障碍患者中的分布没有显著差异。
结论
本研究结果表明，CX3CR1基因V249I（rs3732379）单核苷酸多态性CC基因型与移植肾功能延迟风险增加相关。
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