Saharkhiz Nasrin, Nikbakht Roshan, Salehpour Saghar
Infertility and Reproductive Health Research Center (IRHRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Infertility and IVF, Imam Khomeini Hospital, Jondishapour University of Medical Sciences, Ahwaz, Iran.
Int J Fertil Steril. 2014 Oct;8(3):249-54. Epub 2014 Nov 1.
Embryo transfer (ET) is one of the most important steps in assisted re- productive technology (ART) cycles and affected by many factors namely the depth of embryo deposition in uterus. In this study, the outcomes of intracytoplasmic sperm injec- tion (ICSI) cycles after blind embryo transfer and embryo transfer based on previously measured uterine length using vaginal ultrasound were compared.
This prospective randomised clinical trial included one hun- dred and forty non-donor fresh embryo transfers during January 2010 to June 2011. In group I, ET was performed using conventional (blind) method at 5-6cm from the external os, and in group II, ET was done at a depth of 1-1.5 cm from the uterine fundus based on previously measured uterine length using vaginal sonography. Appropriate statistical analysis was performed using Student's t test and Chi-square or Fisher's exact test. The software that we used was PASW statistics version 18. A p value <0.05 was considered statistically significant.
Chemical pregnancy rate was 28.7% in group I and 42.1% in group II, while the difference was not statistically significant (p=0.105). Clinical pregnancy, ongoing preg- nancy and implantation rates for group I were 21.2%, 17.7%, and 12.8%, while for group II were 33.9%, 33.9%, and 22.1, respectively. In group I and group II, abortion rates were 34.7% and 0%, respectively, indicating a statistically significant difference (p<0.005). No ectopic pregnancy occurred in two groups.
The use of uterine length measurement during treatment cycle in order to place embryos at depth of 1-1.5cm from fundus significantly increases clinical and ongo- ing pregnancy and implantation rates, while leads to a decrease in abortion rate (Registra- tion Number: IRCT2014032512494N1).
胚胎移植（ET）是辅助生殖技术（ART）周期中最重要的步骤之一，受多种因素影响，其中包括胚胎在子宫内的着床深度。在本研究中，比较了盲目胚胎移植与基于先前经阴道超声测量的子宫长度进行胚胎移植后的卵胞浆内单精子注射（ICSI）周期的结果。
这项前瞻性随机临床试验纳入了2010年1月至2011年6月期间的140例非供体新鲜胚胎移植。在第一组中，采用传统（盲目）方法在距宫颈外口5 - 6厘米处进行胚胎移植，在第二组中，根据先前经阴道超声测量的子宫长度，在距子宫底部1 - 1.5厘米深处进行胚胎移植。使用学生t检验、卡方检验或费舍尔精确检验进行适当的统计分析。我们使用的软件是PASW statistics版本18。p值<0.05被认为具有统计学意义。
第一组的化学妊娠率为28.7%，第二组为42.1%，差异无统计学意义（p = 0.105）。第一组的临床妊娠率、持续妊娠率和着床率分别为21.2%、17.7%和12.8%，而第二组分别为33.9%、33.9%和22.1%。在第一组和第二组中，流产率分别为34.7%和0%，差异有统计学意义（p<0.005）。两组均未发生异位妊娠。
在治疗周期中使用子宫长度测量以便将胚胎放置在距子宫底部1 - 1.5厘米深处可显著提高临床妊娠率、持续妊娠率和着床率，同时降低流产率（注册号：IRCT2014032512494N1）。
