Hoirisch-Clapauch Silvia, Nardi Antonio Egidio, Gris Jean-Christophe, Brenner Benjamin
Department of Hematology, Hospital Federal dos Servidores do Estado, Ministry of Health, Rio de Janeiro, Brazil;
Institute of Psychiatry, Federal University of Rio de Janeiro, National Institute for Translational Medicine (INCT-TM), Brazil;
Rambam Maimonides Med J. 2014 Oct 29;5(4):e0036. doi: 10.5041/RMMJ.10170. eCollection 2014 Oct.
The neurovascular unit is a key player in brain development, homeostasis, and pathology. Mental stress affects coagulation, while severe mental illnesses, such as recurrent depression and schizophrenia, are associated with an increased thrombotic risk and cardiovascular morbidity. Evidence indicates that the hemostatic system is involved to some extent in the pathogenesis, morbidity, and prognosis of a wide variety of psychiatric disorders. The current review focuses on emerging data linking coagulation and some psychiatric disorders.
神经血管单元在大脑发育、内环境稳定及病理学中起着关键作用。精神压力会影响凝血，而严重精神疾病，如复发性抑郁症和精神分裂症，与血栓形成风险增加及心血管疾病发病率升高有关。有证据表明，止血系统在多种精神障碍的发病机制、发病率及预后中均有一定程度的参与。本综述聚焦于将凝血与某些精神障碍联系起来的新数据。
