一个AP-2元件与人前脑啡肽原基因的环磷酸腺苷和佛波酯诱导增强子协同作用。
An AP-2 element acts synergistically with the cyclic AMP- and phorbol ester-inducible enhancer of the human proenkephalin gene.
作者信息
Hyman S E, Comb M, Pearlberg J, Goodman H M
机构信息
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.
出版信息
Mol Cell Biol. 1989 Jan;9(1):321-4. doi: 10.1128/mcb.9.1.321-324.1989.
Abstract
An enhancer with two DNA elements, one containing the sequence CGTCA, is required for cyclic AMP- and phorbol ester-inducible transcription of the human proenkephalin gene. We report that an AP-2 element located adjacent to the enhancer acts synergistically with it to confer maximal response to cyclic AMP and phorbol esters.
摘要
人前脑啡肽原基因的环磷酸腺苷（cAMP）和佛波酯诱导型转录需要一个具有两个DNA元件的增强子，其中一个元件包含CGTCA序列。我们报道，位于该增强子附近的一个AP-2元件与其协同作用，赋予对cAMP和佛波酯的最大反应。
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