An AP-2 element acts synergistically with the cyclic AMP- and phorbol ester-inducible enhancer of the human proenkephalin gene.
作者信息
Hyman S E, Comb M, Pearlberg J, Goodman H M
机构信息
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.
出版信息
Mol Cell Biol. 1989 Jan;9(1):321-4. doi: 10.1128/mcb.9.1.321-324.1989.
Abstract
An enhancer with two DNA elements, one containing the sequence CGTCA, is required for cyclic AMP- and phorbol ester-inducible transcription of the human proenkephalin gene. We report that an AP-2 element located adjacent to the enhancer acts synergistically with it to confer maximal response to cyclic AMP and phorbol esters.
摘要
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