干扰素β相关性视网膜病变
INTERFERON-β-ASSOCIATED RETINOPATHY.
作者信息
Martinez de Aragon Javier S, Pulido Jose S, Haupert Christopher L, Blodi Christopher F, Nielsen Jared S, Jampol Lee M
机构信息
From *the Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota; †Iowa Retina Consultants, West Des Moines, Iowa; and ‡the Department of Ophthalmology, Northwestern University, Chicago, Illinois.
出版信息
Retin Cases Brief Rep. 2009 Winter;3(1):24-6. doi: 10.1097/ICB.0b013e31814b160d.
BACKGROUND
Interferon-associated retinopathy is a rare complication of interferon treatment. It has been well described with the use of interferon-α.
METHODS
This study reports a retrospective case series of interferon-β-associated retinopathy in three patients that were being treated for multiple sclerosis.
RESULTS
All cases were characterized by cotton-wool spots or peripheral microaneurysms. One central retinal artery occlusion was observed associated with interferon-β treatment. Findings improved spontaneously in two of three cases; all three patients elected to continue interferon treatment.
CONCLUSION
Patients being treated with interferon-β should have periodic fundus examinations to determine if they have evidence of interferon-associated retinopathy.
背景
干扰素相关性视网膜病变是干扰素治疗的一种罕见并发症。使用干扰素-α时对此已有充分描述。
方法
本研究报告了3例正在接受多发性硬化治疗的患者发生干扰素-β相关性视网膜病变的回顾性病例系列。
结果
所有病例均以棉絮斑或周边微动脉瘤为特征。观察到1例与干扰素-β治疗相关的视网膜中央动脉阻塞。3例中有2例病情自发改善；所有3例患者均选择继续干扰素治疗。
结论
接受干扰素-β治疗的患者应定期进行眼底检查，以确定是否有干扰素相关性视网膜病变的证据。
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