Abd El-Badie Mohamed Mahmoud, Abd-El Azeem Eed Khaled
Ophthalmology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Clin Ophthalmol. 2012;6:1341-5. doi: 10.2147/OPTH.S32469. Epub 2012 Aug 20.
To evaluate retinopathy associated with interferon therapy in patients with chronic hepatitis C.
One hundred patients with chronic hepatitis C undergoing interferon therapy were examined for the presence of cotton wool spots, retinal hemorrhages, cystoid macular edema, capillary non-perfusion, and arteriolar occlusion. Complete ophthalmological examination including indirect ophthalmoscopic fundus examination was carried out for all patients and colored fundus photography and fluorescein angiography were carried out for the patients with positive fundus findings. The follow-up period was 9 months.
Sixteen percent of patients developed retinopathy in the form of cotton wool spots, retinal hemorrhages, cystoid macular edema, and capillary non-perfusion.
Interferon therapy can lead to retinopathy which is mostly reversible and dose related. Periodic fundoscopic examinations help in early detection and prevent progression to permanent visual loss.
评估慢性丙型肝炎患者接受干扰素治疗时相关的视网膜病变。
对100例接受干扰素治疗的慢性丙型肝炎患者检查是否存在棉絮斑、视网膜出血、黄斑囊样水肿、毛细血管无灌注和小动脉阻塞。对所有患者进行包括间接检眼镜眼底检查在内的全面眼科检查，对眼底检查结果呈阳性的患者进行彩色眼底照相和荧光素血管造影。随访期为9个月。
16%的患者出现以棉絮斑、视网膜出血、黄斑囊样水肿和毛细血管无灌注形式的视网膜病变。
干扰素治疗可导致视网膜病变，这种病变大多可逆且与剂量相关。定期眼底检查有助于早期发现并防止进展为永久性视力丧失。
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