Vollebregt Madelon A, van Dongen-Boomsma Martine, Slaats-Willemse Dorine, Buitelaar Jan K, Oostenveld Robert
Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, Netherlands Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Nijmegen, Netherlands Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Nijmegen, Netherlands
Radboud University Medical Centre, Department of Psychiatry, Nijmegen, Netherlands Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, Netherlands Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Nijmegen, Netherlands.
Clin EEG Neurosci. 2015 Oct;46(4):285-91. doi: 10.1177/1550059414537257. Epub 2014 Nov 11.
Attention-deficit/hyperactivity disorder (ADHD) has been associated with an elevated resting-state theta/beta power ratio and elevated theta power. However, the potential confounding effect of a low individual alpha peak frequency (IAPF) on the theta-power estimate has often been disregarded when studying the relationship between ADHD and the theta/beta power ratio or theta power alone. The aim of the present study was to assess whether the theta/beta power ratio and relative theta power are correlated with behavioral functioning in children with ADHD, as expected from previous studies. Subsequently, the influence of IAPF and the amount of supposed overlap between the individually determined alpha-band and the fixed theta-band were studied. For 38 children (aged 8-15 years), electroencephalographic (EEG) and investigator-scored ADHD Rating Scale IV data were available. Additional neurocognitive data were available for 32 children. As expected, the theta/beta power ratio and theta were positively related to the ADHD core symptoms. This relationship strengthened when controlling for IAPF, although correlations did not significantly differ from one another. Eight of 38 children (21%) showed a supposed overlap between their individually determined alpha band and the theta band. Neurocognitive performance did not show any relationship with the theta/beta power ratio or theta. The results of this study confirm that the theta/beta power ratio and theta power are indeed correlated with behavioral symptoms in children with ADHD and underscore the relevance of taking the IAPF into account.
注意缺陷多动障碍（ADHD）与静息态θ/β功率比升高及θ功率升高有关。然而，在单独研究ADHD与θ/β功率比或θ功率之间的关系时，个体α峰值频率（IAPF）较低对θ功率估计的潜在混杂效应常常被忽视。本研究的目的是评估θ/β功率比和相对θ功率是否如先前研究所预期的那样与ADHD儿童的行为功能相关。随后，研究了IAPF的影响以及个体确定的α波段与固定θ波段之间假定的重叠量。有38名儿童（8至15岁）的脑电图（EEG）和研究者评分的ADHD评定量表IV数据可用。另有32名儿童有额外的神经认知数据。正如预期的那样，θ/β功率比和θ与ADHD核心症状呈正相关。在控制IAPF后，这种关系得到加强，尽管相关性之间没有显著差异。38名儿童中有8名（21%）在其个体确定的α波段与θ波段之间显示出假定的重叠。神经认知表现与θ/β功率比或θ没有任何关系。本研究结果证实，θ/β功率比和θ功率确实与ADHD儿童的行为症状相关，并强调了考虑IAPF的相关性。
