Akakpo William, Burnett Arthur L
Service d'Urologie, Groupe Hospitalier Privé Ambroise Paré, Neuilly sur Seine, France.
The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Int J Impot Res. 2025 Apr 11. doi: 10.1038/s41443-025-01026-5.
Priapism is an erectile disorder with persistent and uncontrolled erections without sexual purpose. Ischemic priapism is the most frequent form of priapism and sickle cell disease is a risk factor to develop ischemic priapism with prevalence rates between 30% and 40%. The clear pathogenesis of sickle cell is still under investigation but various mechanisms including nitric oxide, phosphodiesterase type 5, opiorphin and adenosine, testosterone, RhoA/ROCK modulated by oxidative stress and genetic features are known to be key factors of this vascular disease. In this review, we explore these multiple regulatory pathways involved in the pathophysiology of priapism.
阴茎异常勃起是一种勃起功能障碍，表现为无性欲目的的持续性和不受控制的勃起。缺血性阴茎异常勃起是阴茎异常勃起最常见的形式，镰状细胞病是发生缺血性阴茎异常勃起的一个危险因素，患病率在30%至40%之间。镰状细胞病的确切发病机制仍在研究中，但包括一氧化氮、5型磷酸二酯酶、阿片肽和腺苷、睾酮、受氧化应激调节的RhoA/ROCK以及遗传特征等多种机制已知是这种血管疾病的关键因素。在本综述中，我们探讨了阴茎异常勃起病理生理学中涉及的这些多种调节途径。
