Jones N P
The Royal Eye Hospital , Manchester , United Kingdom.
Ocul Immunol Inflamm. 2015 Apr;23(2):127-34. doi: 10.3109/09273948.2014.968671. Epub 2014 Nov 13.
To demonstrate the manifestations and complications of uveitis, and their medical and surgical management, in a very large group of patients attending the Manchester Uveitis Clinic (MUC), a specialist uveitis clinic in the Northwest of England, UK.
Retrospective retrieval of data on a computerized database incorporating all new referrals to MUC from 1991 to 2013.
A total of 3000 new patients with uveitis were seen during a 22-year period, of which 25.2% had a single acute episode, 13.6% had acute recurrent uveitis, 20.2% had chronic fluctuating uveitis, and 41.0% had chronic unremitting uveitis. The commonest complications were cataract (35% of patients), macular edema (20.5%), and glaucoma (19.5%). Oral steroids were required in 36% of patients, oral immunosuppression in 16%, and biologic treatment in 2%. Major intraocular surgery was required in 28%.
Oral steroid usage is not an independent risk factor for cataract formation in patients with uveitis. Oral immunosuppression usage has increased 4-fold during this study period.
在英国西北部一家专业葡萄膜炎诊所——曼彻斯特葡萄膜炎诊所（MUC）就诊的大量患者中，展示葡萄膜炎的表现、并发症及其药物和手术治疗方法。
回顾性检索1991年至2013年期间录入MUC计算机数据库的所有新转诊患者的数据。
在22年期间，共诊治了3000例葡萄膜炎新患者，其中25.2%为单次急性发作，13.6%为急性复发性葡萄膜炎，20.2%为慢性波动性葡萄膜炎，41.0%为慢性持续性葡萄膜炎。最常见的并发症是白内障（35%的患者）、黄斑水肿（20.5%）和青光眼（19.5%）。36%的患者需要口服类固醇，16%需要口服免疫抑制剂，2%需要生物治疗。28%的患者需要进行主要的眼内手术。
口服类固醇的使用并非葡萄膜炎患者白内障形成的独立危险因素。在本研究期间，口服免疫抑制剂的使用增加了4倍。
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