Sonalkar Sarita, Kapp Nathalie
* University of Pennsylvania , Philadelphia, PA , USA.
Eur J Contracept Reprod Health Care. 2015 Feb;20(1):4-18. doi: 10.3109/13625187.2014.971454. Epub 2014 Nov 14.
Given new research on postpartum placement of levonorgestrel and copper intrauterine devices (IUDs), our objective was to update a prior systematic review of the safety and expulsion rates of postpartum IUDs.
We searched MEDLINE, CENTRAL, LILACS, POPLINE, Web of Science, and ClinicalTrials.gov databases for articles between the database inception until July 2013. We included studies that compared IUD insertion time intervals and routes during the postpartum period. We used standard abstract forms and the United States Preventive Services Task Force grading system to summarise and assess the quality of the evidence.
We included 18 articles. New evidence suggests that a levonorgestrel releasing-intrauterine system (LNG-IUS) insertion within 48 hours of delivery is safe. Postplacental insertion and insertion between 10 minutes and 48 hours after delivery result in higher expulsion rates than insertion 4 to 6 weeks postpartum, or non-postpartum insertion. Insertion at the time of caesarean section is associated with lower expulsion rates than postplacental insertion at the time of vaginal delivery.
This review supports the evidence that insertion of an intrauterine contraceptive within the first 48 hours of vaginal or caesarean delivery is safe. Expulsion rates should be further studied in larger randomised controlled trials.
鉴于左炔诺孕酮和铜宫内节育器(IUD)产后放置的新研究,我们的目的是更新先前关于产后IUD安全性和脱落率的系统评价。
我们检索了MEDLINE、CENTRAL、LILACS、POPLINE、科学网和ClinicalTrials.gov数据库,查找从数据库建立至2013年7月期间的文章。我们纳入了比较产后不同IUD放置时间间隔和途径的研究。我们使用标准摘要表格和美国预防服务工作组分级系统来总结和评估证据质量。
我们纳入了18篇文章。新证据表明,在分娩后48小时内放置左炔诺孕酮宫内节育系统(LNG-IUS)是安全的。胎盘娩出后放置以及在分娩后10分钟至48小时之间放置,其脱落率高于产后4至6周放置或非产后放置。剖宫产时放置的脱落率低于阴道分娩时胎盘娩出后放置。
本评价支持以下证据,即在阴道分娩或剖宫产的头48小时内放置宫内节育器是安全的。脱落率应在更大规模的随机对照试验中进一步研究。