Jansen K L, Dragunow M, Faull R L
Department of Anatomy, University of Auckland Medical School, New Zealand.
Brain Res. 1989 Mar 13;482(1):174-8. doi: 10.1016/0006-8993(89)90557-x.
The distribution of [3H]glycine binding sites was compared with that of N-methyl-D-aspartate (NMDA) receptors labelled with L-[3H]glutamate, and with that of phencyclidine (PCP) receptors labelled with [3H]1-(1-(2-thienyl)-cyclohexyl)piperidine ([3H]TCP) in sections from 7 normal human hippocampi. The results indicate that strychnine-insensitive glycine binding sites are present in high concentrations in CA1 and the molecular layer of the dentate gyrus. This distribution is very similar to the distributions of NMDA and PCP receptors in the human hippocampus.
在取自7个正常人海马体的切片中，将[3H]甘氨酸结合位点的分布与用L-[3H]谷氨酸标记的N-甲基-D-天冬氨酸（NMDA）受体以及用[3H]1-(1-(2-噻吩基)-环己基)哌啶（[3H]TCP）标记的苯环利定（PCP）受体的分布进行了比较。结果表明，士的宁不敏感的甘氨酸结合位点在CA1区和齿状回分子层中浓度很高。这种分布与人海马体中NMDA和PCP受体的分布非常相似。
