Contreras P C, Quirion R, O'Donohue T L
Neurosci Lett. 1986 Jun 18;67(2):101-6. doi: 10.1016/0304-3940(86)90380-0.
The distribution of phencyclidine (PCP) receptors in the rat brain was determined by autoradiography using 1-(1-(2-thienyl)cyclohexyl)piperidine ([3H]TCP). [3H]TCP appeared to bind to PCP receptors as only PCP-like drugs and sigma-opioids inhibited the binding of [3H]TCP. The areas of the rat brain with the highest density of radiolabeled binding sites were the superficial layers of cerebral cortex, hippocampus and dentate gyrus. Moderate densities of binding sites were found in the medial geniculate nuclei, caudate nucleus, nucleus accumbens, interpeduncular nucleus, superior colliculus, periaqueductal gray and cerebellum. Low densities of binding sites were observed in spinal cord, most of the brainstem, the substantia nigra and most of the hypothalamus.
使用1-(1-(2-噻吩基)环己基)哌啶([3H]TCP)通过放射自显影法测定了大鼠脑中苯环己哌啶(PCP)受体的分布。[3H]TCP似乎与PCP受体结合，因为只有PCP样药物和σ-阿片类药物能抑制[3H]TCP的结合。大鼠脑中放射性标记结合位点密度最高的区域是大脑皮层浅层、海马体和齿状回。在内侧膝状体核、尾状核、伏隔核、脚间核、上丘、导水管周围灰质和小脑中发现了中等密度的结合位点。在脊髓、大部分脑干、黑质和大部分下丘脑观察到低密度的结合位点。
