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免疫功能正常的老年患者中表现为直肠癌的巨细胞病毒性直肠炎:一例报告

Cytomegalovirus proctitis mimicking rectal cancer in an immunocompetent elderly patient: a case report.

作者信息

Subbarao Sathyavani, O'Sullivan Anthony, Adesina Tolu, Gwozdz Adam M, Rees Julia, Satta Giovanni

机构信息

Department of Pathology, North Middlesex University Hospital, Sterling Way, N181QX London, UK.

出版信息

BMC Res Notes. 2014 Nov 15;7:799. doi: 10.1186/1756-0500-7-799.

Abstract

BACKGROUND

Cytomegalovirus infection is associated with significant morbidity and mortality in immunocompromised patients, but its impact on immunocompetent patients is still poorly understood. Furthermore, there is increasing evidence implying that chronic infection may contribute to a heightened cardiovascular risk.

CASE PRESENTATION

We describe the case of incidental diagnosis of Cytomegalovirus proctitis in an immune-competent white British elderly gentleman, admitted following a stroke and investigated for rectal cancer following the development of bloody diarrhoea and persistent systemic inflammatory response.

CONCLUSION

This raised some several interesting points; firstly that we must revise our approach to investigating the immunocompetent elderly patient, secondly, could chronic Cytomegalovirus infection have contributed to the presentation of stroke in this patient and lastly what are the existing evidence for treatment in this population? We use this opportunity to try and address some of these questions and feel that this would be of benefit to the wider audience.We discuss the risk factors for disease in immune-competent patients and also a brief overview of the benefits of treatment in this population.

摘要

背景

巨细胞病毒感染在免疫功能低下的患者中与显著的发病率和死亡率相关,但其对免疫功能正常患者的影响仍知之甚少。此外,越来越多的证据表明慢性感染可能会增加心血管疾病风险。

病例报告

我们描述了一例在一名免疫功能正常的英国白人老年男性中偶然诊断出巨细胞病毒直肠炎的病例。该患者因中风入院,在出现血性腹泻和持续的全身炎症反应后接受了直肠癌检查。

结论

这引发了几个有趣的问题;首先,我们必须修订对免疫功能正常的老年患者的检查方法;其次,慢性巨细胞病毒感染是否可能导致了该患者的中风;最后,针对这一人群的治疗现有哪些证据?我们借此机会尝试解决其中一些问题,并认为这将使更广泛的受众受益。我们讨论了免疫功能正常患者疾病的危险因素,并简要概述了该人群治疗的益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e36c/4242482/266a83659217/13104_2013_3325_Fig1_HTML.jpg

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