Department of Pharmacology, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York, USA.
Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Arkansas, USA.
Clin Pharmacol Ther. 2014 Dec;96(6):629-33. doi: 10.1038/clpt.2014.177.
Mitochondrial medicine is an evolving discipline whose importance derives from the central function of mitochondria in adenosine triphosphate (ATP) production, generation of reactive oxygen species, and cell death by necrosis or apoptosis. Consequently, mitochondrial dysfunction plays an important role in the progression of aging and the pathophysiology of many common diseases and off-target drug effects. This provides an impetus for the development of mitochondrial pharmacology, and some promising therapeutic targets for mitochondrial protective therapy have been identified.
线粒体医学是一门不断发展的学科，其重要性源于线粒体在三磷酸腺苷（ATP）生成、活性氧产生以及通过坏死或细胞凋亡导致细胞死亡中的核心功能。因此，线粒体功能障碍在衰老的进展和许多常见疾病的病理生理学以及药物的脱靶效应中起着重要作用。这为线粒体药理学的发展提供了动力，并且已经确定了一些有希望的线粒体保护治疗的治疗靶点。
