Pabón Mibel M, Ji Xun-Ming, Fernandez Jamie Winderbaum, Borlongan Cesar V
Department of Neurosurgery and Brain Repair, Morsani College of Medicine, University of South Florida College of Medicine, Tampa, FL, USA.
CNS Neurosci Ther. 2015 Apr;21(4):348-56. doi: 10.1111/cns.12339. Epub 2014 Nov 15.
Stroke is a significant unmet clinical need. The current stroke treatment of tissue plasminogen activator is limited to the very acute 4.5 h after disease onset which benefits only less than 3% of ischemic stroke patients. Our overarching hypothesis advances the notion that gender, which has been established as a comorbidity factor of stroke, plays a key role in regenerative medicine, in particular stem cell therapy. We hypothesize that gender is a key factor in culture-induced stemness of adult stem cells. Our goal is to provide new evidence supporting gender effects on stroke and stem cells for the purpose of enhancing our understanding of the pathophysiology of the disease and developing novel stem cell-based therapeutics targeting gender-relevant stress hormones as manifested in a stroke-postpartum depression paradigm.
中风是一项尚未得到满足的重大临床需求。目前用于中风治疗的组织纤溶酶原激活剂仅限于发病后非常短暂的4.5小时内使用，受益的缺血性中风患者不到3%。我们的总体假设提出了这样一种观点，即性别作为已确定的中风合并症因素，在再生医学尤其是干细胞治疗中起着关键作用。我们假设性别是成年干细胞培养诱导干性的关键因素。我们的目标是提供新的证据，支持性别对中风和干细胞的影响，以增进我们对该疾病病理生理学的理解，并开发基于干细胞的新型疗法，针对产后抑郁症中风范式中表现出的与性别相关的应激激素。
