双胎早产儿视网膜病变发生危险因素的差异：一项中国人群研究
Differences in risk factors for retinopathy of prematurity development in paired twins: a Chinese population study.
作者信息
Yau Gordon S K, Lee Jacky W Y, Tam Victor T Y, Yip Stan, Cheng Edith, Liu Catherine C L, Chu Benjamin C Y, Yuen Can Y F
机构信息
Department of Ophthalmology, Caritas Medical Centre, 111 Wing Hong Street, Kowloon, Hong Kong.
Department of Applied Mathematics, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
出版信息
ScientificWorldJournal. 2014;2014:212183. doi: 10.1155/2014/212183. Epub 2014 Oct 23.
PURPOSE
To determine the differences in risk factors for retinopathy of prematurity (ROP) in paired twins.
METHODS
A retrospective medical record review was performed for all paired twins screened for ROP between 2007 and 2012. Screening was offered to very low birth weight (≤ 1500 grams) and preterm (≤ 32 weeks) neonates. Twins 1 and 2 were categorized based on the order of delivery. Maternal and neonatal covariates were analyzed using univariate and multivariate regression analyses for both ROP and Type 1 ROP.
RESULTS
In 34 pairs of Chinese twins, the mean gestational age (GA) was 30.2 ± 2.0 weeks. In Twin 1, smaller GA (OR = 0.44, P = 0.02), higher mean oxygen concentration (OR = 1.34, P = 0.03), presence of thrombocytopenia (OR = 1429.60, P < 0.0001), and intraventricular hemorrhage (OR = 18.67, P = 0.03) were significant risk factors for ROP. For Twin 2, a smaller GA (OR = 0.45, P = 0.03) was the only risk factor. There were no significant risk factors for ROP in Twin 1 or Twin 2 on multivariate analysis.
CONCLUSION
In Chinese twin pairs, smaller GA was the only common risk factor for ROP while Twin 1 was more susceptible to the postnatal risks for ROP.
目的
确定配对双胞胎中早产儿视网膜病变（ROP）危险因素的差异。
方法
对2007年至2012年间所有接受ROP筛查的配对双胞胎进行回顾性病历审查。对极低出生体重（≤1500克）和早产（≤32周）的新生儿进行筛查。双胞胎1和2根据分娩顺序分类。对ROP和1型ROP的母体和新生儿协变量进行单变量和多变量回归分析。
结果
在34对中国双胞胎中，平均胎龄（GA）为30.2±2.0周。在双胞胎1中，较小的GA（OR = 0.44，P = 0.02）、较高的平均氧浓度（OR = 1.34，P = 0.03）、血小板减少症的存在（OR = 1429.60，P < 0.0001）和脑室内出血（OR = 18.67，P = 0.03）是ROP的显著危险因素。对于双胞胎2，较小的GA（OR = 0.45，P = 0.03）是唯一的危险因素。多变量分析显示，双胞胎1或双胞胎2中ROP均无显著危险因素。
结论
在中国双胞胎中，较小的GA是ROP唯一的共同危险因素，而双胞胎1更容易受到ROP的出生后风险影响。
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