J Antimicrob Chemother. 1989 Feb;23(2):261-6. doi: 10.1093/jac/23.2.261.
Five hundred and twenty-eight patients with a clinical diagnosis of bacterial conjunctivitis were enrolled in four randomized, double-blind, parallel studies. Patients were treated with trimethoprim-polymyxin B sulphate (TP) or chloramphenicol ophthalmic ointments, four times a day for seven days in three studies, and three times a day for five days in one. Data suitable for evaluation of efficacy and safety were obtained from 448 patients. The results of each study were analysed separately and indicated that both treatments were effective and well tolerated and that there were no statistically significant differences between them. However, in three studies, efficacy trends generally favoured TP ophthalmic ointment and in one study efficacy trends favoured chloramphenicol ophthalmic ointment. A wide range of pathogenic or potentially pathogenic organisms was isolated, with Haemophilus influenzae being the most prevalent.
528例临床诊断为细菌性结膜炎的患者参与了四项随机、双盲、平行研究。在三项研究中，患者接受硫酸三甲氧苄氨嘧啶-多粘菌素B（TP）或氯霉素眼膏治疗，每日4次，共7天；在另一项研究中，每日3次，共5天。从448例患者中获得了适合评估疗效和安全性的数据。每项研究的结果分别进行分析，结果表明两种治疗方法均有效且耐受性良好，两者之间无统计学显著差异。然而，在三项研究中，疗效趋势总体上更倾向于TP眼膏，在一项研究中，疗效趋势更倾向于氯霉素眼膏。分离出了多种致病或潜在致病生物体，其中流感嗜血杆菌最为常见。
