Bae Jong Bin, Kim You Joung, Han Ji Won, Kim Tae Hui, Park Joon Hyuk, Lee Seok Bum, Lee Jung Jae, Jeong Hyun Ghang, Kim Jeong Lan, Jhoo Jin Hyeong, Yoon Jong Chul, Kim Ki Woong
Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.
Dement Geriatr Cogn Disord. 2015;39(1-2):105-15. doi: 10.1159/000366555. Epub 2014 Nov 11.
BACKGROUND/AIMS: Knowledge of incidence rates and risk factors is essential for the development of strategies to treat patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI).
A subpopulation of the Nationwide Survey on Dementia Epidemiology (460 Korean subjects aged ≥65 years from 2 rural and 2 urban districts) was followed up for 3.5 years. The age-specific incidence was estimated and risk factors were identified.
The age-standardized incidence of AD and MCI was 7.9 and 28.1 cases per 1,000 person-years, respectively. MCI was associated with a 6-fold increased risk of AD. Depression was a risk factor for AD with MCI. Age, lack of formal education, illiteracy, rural residence, and marital status were associated with the risk of AD.
Strategies to control modifiable risk factors should be implemented to decrease the incidence of AD.
背景/目的：了解发病率和风险因素对于制定治疗阿尔茨海默病（AD）和轻度认知障碍（MCI）患者的策略至关重要。
对全国痴呆症流行病学调查的一个亚组（来自2个农村和2个城市地区的460名年龄≥65岁的韩国受试者）进行了3.5年的随访。估计了特定年龄的发病率并确定了风险因素。
AD和MCI的年龄标准化发病率分别为每1000人年7.9例和28.1例。MCI与AD风险增加6倍相关。抑郁症是伴有MCI的AD的一个风险因素。年龄、未接受正规教育、文盲、农村居住和婚姻状况与AD风险相关。
应实施控制可改变风险因素的策略以降低AD的发病率。
