Nam Joo Hyun, Lee Dong-Ung
Department of Physiology, Dongguk University College of Medicine, Kyungju, Republic of Korea.
Division of Bioscience, Dongguk University, Gyeongju, Republic of Korea.
Planta Med. 2015 Jan;81(1):20-5. doi: 10.1055/s-0034-1383304. Epub 2014 Nov 17.
Cyperus rotundus is used as an analgesic and sedative in oriental medicine and has been reported to exhibit antinociceptive and anti-inflammatory effects. On the other hand, the transient receptor potential vanilloid 1 channel is a nonselective cation channel that senses various noxious chemical and thermal stimuli. However, it has recently been reported that the epidermally expressed transient receptor potential vanilloid 1 channel is involved in heat- and UV-induced skin aging. The aim of this study was to evaluate whether C. rotundus extract and its constituents can inhibit this channel. Ethylacetate and hexane fractions of the methanol extract were found to partially inhibit transient receptor potential vanilloid 1 channel activity, and at a concentration of 90 µM, oleanolic acid, which was one of three constituents isolated from the ethylacetate fraction, inhibited this activity by 61.4 ± 8.0 %. This is first electrophysiological study to be conducted on the effects of C. rotundus extract and its constituents on the transient receptor potential vanilloid 1 channel. The results obtained provide insight of the potential therapeutic effects of C. rotundus in the contexts of analgesia and UV-induced photoaging.
香附在传统医学中用作止痛和镇静剂，据报道具有抗伤害性感受和抗炎作用。另一方面，瞬时受体电位香草酸亚型1通道是一种非选择性阳离子通道，可感知各种有害化学和热刺激。然而，最近有报道称，表皮表达的瞬时受体电位香草酸亚型1通道参与热和紫外线诱导的皮肤老化。本研究的目的是评估香附提取物及其成分是否能抑制该通道。发现甲醇提取物的乙酸乙酯和己烷馏分可部分抑制瞬时受体电位香草酸亚型1通道活性，在浓度为90µM时，从乙酸乙酯馏分中分离出的三种成分之一齐墩果酸可将该活性抑制61.4±8.0%。这是首次关于香附提取物及其成分对瞬时受体电位香草酸亚型1通道影响的电生理研究。所得结果为香附在镇痛和紫外线诱导的光老化方面的潜在治疗作用提供了见解。
