庆大霉素对未成熟动物听觉分析器的影响。
Effect of gentamicin on the auditory analyzer in sexually immature animals.
作者信息
D'yakonova I N, Ishanova Yu S, Rakhmanova I V, Tikhomirov A M
机构信息
Department of Physiology, Medicobiological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2014 Nov;158(1):61-5. doi: 10.1007/s10517-014-2692-9. Epub 2014 Nov 19.
Auditory function of immature rabbits was evaluated using two electrophysiological methods, brainstem auditory evoked response (BAER) and distortion product otoacoustic emission (DPOAE), in chronic experiments following administration of therapeutic doses of gentamicin. Impairment of auditory function manifested in increased thresholds and decreased amplitude of the 1st BAER peak was established. DPOAE parameters were not significantly changed. It was suggested that gentamicin decreased activity of spiral ganglion neurocytes in animals with immature auditory analyzer.
在给予治疗剂量庆大霉素后的慢性实验中，采用脑干听觉诱发电位（BAER）和畸变产物耳声发射（DPOAE）这两种电生理方法评估未成熟兔的听觉功能。确定听觉功能损害表现为BAER第一个峰的阈值升高和幅度降低。DPOAE参数无显著变化。提示庆大霉素降低了听觉分析器未成熟动物螺旋神经节神经细胞的活性。
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