Gao Weisong, Huang Wenyan, Liu Kaishan
Department of Pathology, Medical College, Ji'nan University, Guangzhou 510632, China.
Zhongguo Fei Ai Za Zhi. 2014 Nov;17(11):819-23. doi: 10.3779/j.issn.1009-3419.2014.11.08.
Lung cancer is the leading cause of cancer deaths throughout the world. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. In traditional anti-cancer therapy, promotion of apoptosis in NSCLC is an important part of treatment, but anticancer drugs have the toxic side effects, resistance and other problems. Therefore, the search for new targets of anticancer drugs becomes one of the foci in the treatment of NSCLC. The BH3-only protein plays an important role in activation and communication in apoptosis pathways. BIM is the core member in BH3-only protein family. The target at BIM in the treatment of NSCLC has an irreplaceable role. This paper briefly describes the BCL-2 family and BH3-only pro-apoptotic protein, elaborates the important role of BIM and BH3-only protein in targeted therapy of NSCLC.
肺癌是全球癌症死亡的主要原因。非小细胞肺癌（NSCLC）是最常见的肺癌类型。在传统抗癌治疗中，促进NSCLC细胞凋亡是治疗的重要组成部分，但抗癌药物存在毒副作用、耐药性等问题。因此，寻找抗癌药物新靶点成为NSCLC治疗的焦点之一。仅含BH3结构域的蛋白在凋亡途径的激活和信号传导中起重要作用。BIM是仅含BH3结构域蛋白家族的核心成员。针对BIM靶点治疗NSCLC具有不可替代的作用。本文简要介绍了BCL-2家族和仅含BH3结构域的促凋亡蛋白，阐述了BIM和仅含BH3结构域蛋白在NSCLC靶向治疗中的重要作用。
