Daianu Madelaine, Jahanshad Neda, Dennis Emily L, Toga Arthur W, McMahon Katie L, de Zubicaray Greig I, Martin Nicholas G, Wright Margaret J, Hickie Ian B, Thompson Paul M
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA.
Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.
Proc IEEE Int Symp Biomed Imaging. 2012 May;2012:526-529. doi: 10.1109/ISBI.2012.6235601.
Diffusion imaging can map anatomical connectivity in the living brain, offering new insights into fundamental questions such as how the left and right brain hemispheres differ. Anatomical brain asymmetries are related to speech and language abilities, but less is known about left/right hemisphere differences in brain wiring. To assess this, we scanned 457 young adults (age 23.4±2.0 SD years) and 112 adolescents (age 12-16) with 4-Tesla 105-gradient high-angular resolution diffusion imaging. We extracted fiber tracts throughout the brain with a Hough transform method. A 70×70 connectivity matrix was created, for each subject, based on the proportion of fibers intersecting 70 cortical regions. We identified significant differences in the proportions of fibers intersecting left and right hemisphere cortical regions. The degree of asymmetry in the connectivity matrices varied with age, as did the asymmetry in network topology measures such as the small-world effect.
扩散成像能够绘制活体大脑中的解剖连接图谱，为诸如左右脑半球如何不同等基本问题提供新的见解。大脑解剖学上的不对称与言语和语言能力相关，但对于大脑布线中左右半球的差异却知之甚少。为了评估这一点，我们使用4特斯拉105梯度高角分辨率扩散成像技术对457名年轻人（年龄23.4±2.0标准差岁）和112名青少年（年龄12 - 16岁）进行了扫描。我们采用霍夫变换方法在整个大脑中提取纤维束。基于与70个皮质区域相交的纤维比例，为每个受试者创建了一个70×70的连接矩阵。我们确定了与左右半球皮质区域相交的纤维比例存在显著差异。连接矩阵中的不对称程度随年龄而变化，网络拓扑测量中的不对称性（如小世界效应）也是如此。
