Guessous Idris, Luthi Jean-Christophe, Bowling Christopher Barrett, Theler Jean-Marc, Paccaud Fred, Gaspoz Jean-Michel, McClellan William
Unit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine, Primary Care, and Emergency Medicine, Geneva University Hospitals, 4 Rue Gabrielle-Perret-Gentil, 1211 Geneva 14, Switzerland ; Community Prevention Unit, University Institute of Social and Preventive Medicine, 10 Route de la Corniche, 1010 Lausanne, Switzerland ; Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA.
Community Prevention Unit, University Institute of Social and Preventive Medicine, 10 Route de la Corniche, 1010 Lausanne, Switzerland.
J Aging Res. 2014;2014:198603. doi: 10.1155/2014/198603. Epub 2014 Oct 22.
Frailty prevalence in older adults has been reported but is largely unknown in middle-aged adults. We determined the prevalence of frailty indicators among middle-aged and older adults from a general Swiss population characterized by universal health insurance coverage and assessed the determinants of frailty with a special focus on socioeconomic status. Participants aged 50 and more from the population-based 2006-2010 Bus Santé study were included (N = 2,930). Four frailty indicators (weakness, shrinking, exhaustion, and low activity) were measured according to standard definitions. Multivariate logistic regressions were used to determine associations. Overall, 63.5%, 28.7%, and 7.8% participants presented no frailty indicators, one frailty indicator, and two or more frailty indicators, respectively. Among middle-aged participants (50-65 years), 75.1%, 22.2%, and 2.7% presented 0, 1, and 2 or more frailty indicators. The number of frailty indicators was positively associated with age, hypertension, and current smoking and negatively associated with male gender, body mass index, waist-to-hip ratio, and serum total cholesterol level. Lower income level but not education was associated with higher number of frailty indicators. Frailty indicators are frequently encountered in both older and middle-aged adults from the Swiss general population. Despite universal health insurance coverage, household income is independently associated with frailty.
已有研究报道了老年人的衰弱患病率，但中年人的衰弱患病率在很大程度上尚不清楚。我们确定了来自具有全民医疗保险覆盖特征的瑞士普通人群的中年和老年人中衰弱指标的患病率，并特别关注社会经济地位，评估了衰弱的决定因素。纳入了基于人群的2006 - 2010年公交健康研究中年龄在50岁及以上的参与者（N = 2,930）。根据标准定义测量了四个衰弱指标（虚弱、消瘦、疲惫和低活动量）。使用多变量逻辑回归来确定关联。总体而言，分别有63.5%、28.7%和7.8%的参与者没有衰弱指标、有一个衰弱指标以及有两个或更多衰弱指标。在中年参与者（50 - 65岁）中，75.1%、22.2%和2.7%的人分别有0、1和2个或更多衰弱指标。衰弱指标的数量与年龄、高血压和当前吸烟呈正相关，与男性性别、体重指数、腰臀比和血清总胆固醇水平呈负相关。较低的收入水平而非教育程度与更多的衰弱指标相关。在瑞士普通人群的老年人和中年人中，衰弱指标很常见。尽管有全民医疗保险覆盖，但家庭收入与衰弱独立相关。
