Sikkes Sietske A M, Rotrou Jocelyne de
Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands.
Neurodegener Dis Manag. 2014;4(5):393-400. doi: 10.2217/nmt.14.24.
The measurement of instrumental activities of daily living (IADL) is common in clinical practice and research into dementia. IADL are cognitively complex daily activities, such as cooking and doing finances. Their measurement is required for the diagnostic process of dementia, and also useful for the monitoring of disease progression. Since problems in IADL contribute to the disease burden of both patient and caregiver, it is a relevant outcome measure for disease-modifying and non-pharmacological interventions. Despite the widespread use of IADL instruments, an overview of its theoretical background, measurement methods, and potential sources of bias is lacking. In the current manuscript, we therefore aim to provide a selective overview of these topics.
日常生活工具性活动(IADL)的测量在痴呆症的临床实践和研究中很常见。IADL是认知复杂的日常活动,如做饭和理财。它们的测量是痴呆症诊断过程所必需的,也有助于监测疾病进展。由于IADL方面的问题会加重患者和照顾者的疾病负担,因此它是疾病修饰和非药物干预的一个相关结局指标。尽管IADL测量工具被广泛使用,但缺乏对其理论背景、测量方法和潜在偏差来源的综述。因此,在本手稿中,我们旨在对这些主题进行选择性综述。