Piguet Camille, Desseilles Martin, Cojan Yann, Sterpenich Virginie, Dayer Alexandre, Bertschy Gilles, Vuilleumier Patrik
Department of Neuroscience, Faculty of Medicine, University of Geneva, 1206 Genève, Switzerland, Cyclotron Research Center, University of Liège, 4000 Liège, Belgium, Department of Psychiatry, Geneva University Hospital, 1205 Genève, Switzerland, Department of Psychiatry and Mental Health, Strasbourg University Hospital, University of Strasbourg, INSERMu1114, 67091 Strasbourg Cedex, France, and Department of Clinical Neuroscience, Geneva University Hospital, 1205 Genève, Switzerland
Department of Neuroscience, Faculty of Medicine, University of Geneva, 1206 Genève, Switzerland, Cyclotron Research Center, University of Liège, 4000 Liège, Belgium, Department of Psychiatry, Geneva University Hospital, 1205 Genève, Switzerland, Department of Psychiatry and Mental Health, Strasbourg University Hospital, University of Strasbourg, INSERMu1114, 67091 Strasbourg Cedex, France, and Department of Clinical Neuroscience, Geneva University Hospital, 1205 Genève, Switzerland Department of Neuroscience, Faculty of Medicine, University of Geneva, 1206 Genève, Switzerland, Cyclotron Research Center, University of Liège, 4000 Liège, Belgium, Department of Psychiatry, Geneva University Hospital, 1205 Genève, Switzerland, Department of Psychiatry and Mental Health, Strasbourg University Hospital, University of Strasbourg, INSERMu1114, 67091 Strasbourg Cedex, France, and Department of Clinical Neuroscience, Geneva University Hospital, 1205 Genève, Switzerland Department of Neuroscience, Faculty of Medicine, University of Geneva, 1206 Genève, Switzerland, Cyclotron Research Center, University of Liège, 4000 Liège, Belgium, Department of Psychiatry, Geneva University Hospital, 1205 Genève, Switzerland, Department of Psychiatry and Mental Health, Strasbourg University Hospital, University of Strasbourg, INSERMu1114, 67091 Strasbourg Cedex, France, and Department of Clinical Neuroscience, Geneva University Hospital, 1205 Genève, Switzerland.
Soc Cogn Affect Neurosci. 2015 Jul;10(7):978-86. doi: 10.1093/scan/nsu146. Epub 2014 Nov 17.
Thought disorders such as rumination or flight of ideas are frequent in patients with mood disorders, and not systematically linked to mood state. These symptoms point to anomalies in cognitive processes mediating the generation and control of thoughts; for example, associative thinking and inhibition. However, their neural substrates are not known.
To obtain an ecological measure of neural processes underlying the generation and suppression of spontaneous thoughts, we designed a free word association task during fMRI allowing us to explore verbal associative patterns in patients with mood disorders and matched controls. Participants were presented with emotionally negative, positive or neutral words, and asked to produce two words either related or unrelated to these stimuli.
Relative to controls, patients produced a reverse pattern of answer typicality for the related vs unrelated conditions. Controls activated larger semantic and executive control networks, as well as basal ganglia, precuneus and middle frontal gyrus. Unlike controls, patients activated fusiform gyrus, parahippocampal gyrus and medial prefrontal cortex for emotional stimuli.
Mood disorder patients are impaired in automated associative processes, but prone to produce more unique/personal associations through activation of memory and self-related areas.
诸如沉思或思维奔逸等思维障碍在心境障碍患者中很常见，且与心境状态无系统性关联。这些症状表明在介导思维产生和控制的认知过程中存在异常；例如，联想思维和抑制。然而，它们的神经基质尚不清楚。
为了获得对自发思维产生和抑制背后神经过程的生态学测量，我们设计了一项功能磁共振成像（fMRI）期间的自由词联想任务，使我们能够探究心境障碍患者及匹配对照组的言语联想模式。向参与者呈现情绪消极、积极或中性的词语，并要求他们给出与这些刺激相关或不相关的两个词语。
相对于对照组，患者在相关与不相关条件下产生了相反的答案典型性模式。对照组激活了更大的语义和执行控制网络，以及基底神经节、楔前叶和额中回。与对照组不同，患者在面对情绪刺激时激活了梭状回、海马旁回和内侧前额叶皮质。
心境障碍患者在自动联想过程中受损，但通过激活记忆和自我相关区域倾向于产生更多独特/个人化的联想。
