Renkema T E, Postma D S, Noordhoek J A, Faber H, Sluiter H J, Kauffman H F
Department of Pulmonology, State University Hospital, Groningen, The Netherlands.
Agents Actions. 1989 Jan;26(1-2):52-4. doi: 10.1007/BF02126560.
Inflammatory reactions are believed to be important in nonspecific bronchial hyperreactivity (BHR). To investigate the potential role for oxidant-mediated modulation of BHR, we investigated oxidative metabolism of polymorphonuclear leukocytes (PMN) from the peripheral blood in 28 nonallergic patients with chronic airflow obstruction (CAO). No difference in O2- generation was found between 14 smokers and 14 ex-smokers with CAO. A significant correlation was found between the degree of BHR and O2- generation of PMN after stimulation with 20 ng/ml phorbol myristate acetate, both in smokers (r = 0.59, p less than 0.01) and in ex-smokers (r = 0.79, p less than 0.01). The results suggest that oxygen radicals in a direct or indirect way may modulate BHR. Thus, in nonallergic patients with CAO, BHR and inflammation may be linked in a similar way as in allergic patients with asthma.
炎症反应被认为在非特异性支气管高反应性（BHR）中起重要作用。为了研究氧化剂介导的BHR调节的潜在作用，我们调查了28例非过敏性慢性气流阻塞（CAO）患者外周血中多形核白细胞（PMN）的氧化代谢。14名吸烟的CAO患者和14名已戒烟的CAO患者之间未发现超氧阴离子生成的差异。在吸烟者（r = 0.59，p < 0.01）和已戒烟者（r = 0.79，p < 0.01）中，用20 ng/ml佛波酯肉豆蔻酸酯刺激后，BHR程度与PMN的超氧阴离子生成之间均存在显著相关性。结果表明，氧自由基可能直接或间接调节BHR。因此，在非过敏性CAO患者中，BHR和炎症可能与过敏性哮喘患者以类似方式相关联。
