Postma D S, Renkema T E, Noordhoek J A, Faber H, Sluiter H J, Kauffman H
Department of Pulmonology, State University Hospital, Groningen, The Netherlands.
Am Rev Respir Dis. 1988 Jan;137(1):57-61. doi: 10.1164/ajrccm/137.1.57.
Inflammatory reactions are believed to be important in nonspecific bronchial hyperreactivity (BHR). To investigate the potential role for oxidant-mediated modulation of BHR, we investigated oxidative metabolism of polymorphonuclear leukocytes (PMN) from the peripheral blood in 28 nonallergic patients with chronic air-flow obstruction (CAO). No difference in O2- was found between 14 smokers and 14 ex-smokers with CAO. A significant correlation was found between the degree of BHR and O2(-)-generation of PMN after stimulation with 20 ng/ml phorbol myristate acetate, both in smokers (r = 0.59, p less than 0.01) and in ex-smokers (r = 0.79, p less than 0.01). In the light of other findings in experimental animal studies, the results suggest a direct or indirect role for O2- in the modulation of BHR. Thus, in nonallergic patients with CAO, BHR and inflammation may be linked in a similar way as in allergic patients with asthma.
炎症反应被认为在非特异性支气管高反应性（BHR）中起重要作用。为了研究氧化剂介导的BHR调节的潜在作用，我们调查了28例患有慢性气流阻塞（CAO）的非过敏性患者外周血中多形核白细胞（PMN）的氧化代谢。14名吸烟的CAO患者和14名已戒烟的CAO患者之间未发现超氧阴离子（O2-）有差异。在吸烟者（r = 0.59，p < 0.01）和已戒烟者（r = 0.79，p < 0.01）中，用20 ng/ml佛波酯肉豆蔻酸酯乙酸盐刺激后，BHR程度与PMN的O2（-）生成之间均存在显著相关性。根据实验动物研究中的其他发现，结果表明O2-在BHR调节中具有直接或间接作用。因此，在患有CAO的非过敏性患者中，BHR和炎症可能以与患有哮喘的过敏性患者类似的方式相关联。
