Zhang Yuan-Da, Gu Fang, Xie Hui-Qing, Ji Chao-Yu, Zhang Xiao-Long, Zhang Yu, Pang Wei-Wei
Baoding Children's Hospital, Baoding, Hebei 071000, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2014 Nov;16(11):1096-9.
To study the changes and significance of serum hydrogen sulfide (H2S) levels in children with benign infantile convulsions associated with mild gastroenteritis (BICE).
Forty-two hospitalized children diagnosed with BICE were recruited to the observation group, and 46 children admitted due to acute gastroenteritis alone were recruited to the control group. Serum H2S levels were measured by a spectrophotometer.
The serum H2S level in the observation group was significantly lower than in the control group (28±12 μmol/L vs 45±10 μmol/L; P<0.01). The patients with a number of convulsions greater than or equal to two had significantly lower serum H2S levels than those with a number less than two (P<0.05). The number of convulsions was negatively correlated with serum H2S level in BICE patients (r=-0.485, P=0.001). When a convulsion exceeded 5 minues in duration, the duration was negatively correlated with serum H2S level (r=-0.736, P=0.004).
The reduction in endogenous H2S level might be one of the causes of convulsions in BICE patients. The degree of reduction in H2S level is associated with the number of convulsions and the duration of convulsion (when it exceeds 5 minues). Further investigation is needed to determine the clinical significance of these results.
研究轻度胃肠炎伴良性婴儿惊厥（BICE）患儿血清硫化氢（H2S）水平的变化及意义。
选取42例住院诊断为BICE的患儿作为观察组，46例单纯因急性胃肠炎入院的患儿作为对照组。采用分光光度计测定血清H2S水平。
观察组血清H2S水平显著低于对照组（28±12 μmol/L对45±10 μmol/L；P<0.01）。惊厥次数大于或等于2次的患者血清H2S水平显著低于惊厥次数小于2次的患者（P<0.05）。BICE患者惊厥次数与血清H2S水平呈负相关（r=-0.485，P=0.001）。当惊厥持续时间超过5分钟时，持续时间与血清H2S水平呈负相关（r=-0.736，P=0.004）。
内源性H2S水平降低可能是BICE患者惊厥的原因之一。H2S水平降低程度与惊厥次数及惊厥持续时间（超过5分钟时）有关。需要进一步研究以确定这些结果的临床意义。
