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术前贫血对乳腺癌患者复发和生存的影响。

Impact of preoperative anemia on relapse and survival in breast cancer patients.

作者信息

Zhang YingJun, Chen YuYang, Chen DongTai, Jiang Yu, Huang Wan, Ouyang HanDong, Xing Wei, Zeng MuSheng, Xie XiaoMing, Zeng Weian

机构信息

Anesthesiology Department, State Key Laboratory in South China, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, Guangzhou, PR China.

出版信息

BMC Cancer. 2014 Nov 18;14:844. doi: 10.1186/1471-2407-14-844.

DOI:10.1186/1471-2407-14-844
PMID:25406979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4242544/
Abstract

BACKGROUND

Previous studies have shown that preoperative anemia is correlated with the prognoses of various solid tumors. This study was performed to determine the effect of preoperative anemia on relapse and survival in patients with breast cancer.

METHODS

A total of 2960 patients with breast cancer who underwent surgery between 2002 and 2008 at the Sun Yat-sen University Cancer Center (Guangzhou, PR China) were evaluated in a retrospective analysis. A total of 2123 qualified patients were divided into an anemic group [hemoglobin (Hb) < 12.0 g/dL, N = 535)] and a nonanemic group (Hb ≥ 12.0 g/dL, N = 1588). The effects of anemia on local relapse-free survival (LRFS), lymph node metastasis-free survival (LNMFS), distant metastasis-free survival (DMFS), relapse-free survival (RFS), and overall survival (OS) were assessed using Kaplan-Meier analysis. Independent prognostic factors were identified in the final multivariate Cox proportional hazards regression model.

RESULTS

Among the 2123 women who qualified for the analysis, 535 (25.2%) had a Hb level < 12.0 g/dL. The Kaplan-Meier curves showed that anemic patients had worse LRFS, LNMFS, DMFS, RFS, and OS than nonanemic patients, even in the same clinical stage of breast cancer. Cox proportional hazards regression model indicated that preoperative anemia was an independent prognostic factor of LRFS, LNMFS, DMFS, RFS, and OS for patients with breast cancer.

CONCLUSIONS

Preoperative anemia was independently associated with poor prognosis of patients with breast cancer.

摘要

背景

既往研究表明，术前贫血与多种实体瘤的预后相关。本研究旨在确定术前贫血对乳腺癌患者复发和生存的影响。

方法

对2002年至2008年期间在中山大学肿瘤防治中心（中国广州）接受手术的2960例乳腺癌患者进行回顾性分析。将2123例符合条件的患者分为贫血组[血红蛋白（Hb）＜12.0 g/dL，N = 535]和非贫血组（Hb≥12.0 g/dL，N = 1588）。采用Kaplan-Meier分析评估贫血对局部无复发生存率（LRFS）、无淋巴结转移生存率（LNMFS）、无远处转移生存率（DMFS）、无复发生存率（RFS）和总生存率（OS）的影响。在最终的多变量Cox比例风险回归模型中确定独立预后因素。

结果

在2123例符合分析条件的女性中，535例（25.2%）的Hb水平＜12.0 g/dL。Kaplan-Meier曲线显示，即使在相同临床分期的乳腺癌患者中，贫血患者的LRFS、LNMFS、DMFS、RFS和OS也比非贫血患者差。Cox比例风险回归模型表明，术前贫血是乳腺癌患者LRFS、LNMFS、DMFS、RFS和OS的独立预后因素。

结论

术前贫血与乳腺癌患者的不良预后独立相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208b/4242544/0b134e2fb55d/12885_2014_5014_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208b/4242544/a07696ac8209/12885_2014_5014_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208b/4242544/1609d89dc81a/12885_2014_5014_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208b/4242544/5205348d7e59/12885_2014_5014_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208b/4242544/14c53b247d27/12885_2014_5014_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208b/4242544/666fe9d1bd90/12885_2014_5014_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208b/4242544/0b134e2fb55d/12885_2014_5014_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208b/4242544/a07696ac8209/12885_2014_5014_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208b/4242544/1609d89dc81a/12885_2014_5014_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208b/4242544/5205348d7e59/12885_2014_5014_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208b/4242544/14c53b247d27/12885_2014_5014_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208b/4242544/666fe9d1bd90/12885_2014_5014_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208b/4242544/0b134e2fb55d/12885_2014_5014_Fig6_HTML.jpg

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本文引用的文献

1
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2
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3
A perspective on the evolution of management of cancer- and chemotherapy-induced anemia.癌症及化疗所致贫血管理的演变视角
红细胞大小因子是消化道外肿瘤相关性贫血早期诊断的敏感指标：一项观察性研究。
Medicine (Baltimore). 2024 Sep 27;103(39):e39736. doi: 10.1097/MD.0000000000039736.
4
The role of laboratory indices on treatment response and survival in breast cancer receiving neoadjuvant chemotherapy.实验室指标在接受新辅助化疗的乳腺癌患者治疗反应和生存中的作用。
Sci Rep. 2024 May 27;14(1):12123. doi: 10.1038/s41598-024-63096-7.
5
The occurrence and risk factors of chemotherapy-induced neutropenia in patients with breast cancer not receiving primary G-CSF prophylaxis.未接受原发性粒细胞集落刺激因子（G-CSF）预防的乳腺癌患者化疗引起的中性粒细胞减少症的发生率及危险因素
Ecancermedicalscience. 2023 Nov 2;17:1618. doi: 10.3332/ecancer.2023.1618. eCollection 2023.
6
Analysis of anemia and iron supplementation among glioblastoma patients reveals sex-biased association between anemia and survival.分析胶质母细胞瘤患者的贫血和补铁状况揭示了贫血与生存之间存在性别偏倚关联。
Sci Rep. 2024 Jan 29;14(1):2389. doi: 10.1038/s41598-024-52492-8.
7
Extracellular water to total body water ratio, a novel predictor of recurrence in patients with colorectal cancer.细胞外水与总体水比率，一种预测结直肠癌患者复发的新指标。
Ann Gastroenterol Surg. 2023 Aug 8;8(1):98-106. doi: 10.1002/ags3.12728. eCollection 2024 Jan.
8
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5
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6
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7
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8
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9
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10
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