Smits Ferdinanda C M, Buddingh Bastiaan C, van Eldijk Mark B, van Hest Jan C M
Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525, AJ, Nijmegen, The Netherlands.
Macromol Biosci. 2015 Jan;15(1):36-51. doi: 10.1002/mabi.201400419. Epub 2014 Nov 19.
Elastin-like polypeptides (ELPs) are characterized by a high sequence control, temperature responsiveness and biocompatibility, which make them highly interesting as smart materials for application in nanomedicine. In particular the construction of ELP-based nanoparticles has recently become a focal point of attention in materials research. This review will give an overview of the ELP-based nanoparticles that have been developed until now and their underlying design principles. First a short introduction on ELPs and their stimulus-responsive behavior will be given. This characteristic has been applied for the development of ELP-based block copolymers that can self-assemble into nanoparticles. Both the fully ELP-based as well as several ELP hybrid materials that have been reported to form nanoparticles will be discussed, which is followed by a concise description of the promising biomedical applications reported for this class of materials.
弹性蛋白样多肽（ELPs）具有高度的序列可控性、温度响应性和生物相容性，这使得它们作为智能材料在纳米医学中的应用极具吸引力。特别是基于ELP的纳米颗粒的构建最近已成为材料研究的一个关注焦点。本综述将概述迄今为止已开发的基于ELP的纳米颗粒及其潜在的设计原理。首先将对ELPs及其刺激响应行为进行简要介绍。这一特性已被应用于开发可自组装成纳米颗粒的基于ELP的嵌段共聚物。将讨论全基于ELP的以及据报道可形成纳米颗粒的几种ELP杂化材料，随后简要描述已报道的这类材料在生物医学方面的应用前景。
