Ma Ning, Dinges David F, Basner Mathias, Rao Hengyi
Center for Functional Neuroimaging, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Sleep. 2015 Feb 1;38(2):233-40. doi: 10.5665/sleep.4404.
Attention is a cognitive domain that can be severely affected by sleep deprivation. Previous neuroimaging studies have used different attention paradigms and reported both increased and reduced brain activation after sleep deprivation. However, due to large variability in sleep deprivation protocols, task paradigms, experimental designs, characteristics of subject populations, and imaging techniques, there is no consensus regarding the effects of sleep loss on the attending brain. The aim of this meta-analysis was to identify brain activations that are commonly altered by acute total sleep deprivation across different attention tasks.
Coordinate-based meta-analysis of neuroimaging studies of performance on attention tasks during experimental sleep deprivation.
The current version of the activation likelihood estimation (ALE) approach was used for meta-analysis. The authors searched published articles and identified 11 sleep deprivation neuroimaging studies using different attention tasks with a total of 185 participants, equaling 81 foci for ALE analysis.
The meta-analysis revealed significantly reduced brain activation in multiple regions following sleep deprivation compared to rested wakefulness, including bilateral intraparietal sulcus, bilateral insula, right prefrontal cortex, medial frontal cortex, and right parahippocampal gyrus. Increased activation was found only in bilateral thalamus after sleep deprivation compared to rested wakefulness.
Acute total sleep deprivation decreases brain activation in the fronto-parietal attention network (prefrontal cortex and intraparietal sulcus) and in the salience network (insula and medial frontal cortex). Increased thalamic activation after sleep deprivation may reflect a complex interaction between the de-arousing effects of sleep loss and the arousing effects of task performance on thalamic activity.
注意力是一个认知领域，会受到睡眠剥夺的严重影响。以往的神经影像学研究采用了不同的注意力范式，并报告了睡眠剥夺后大脑激活增加和减少的情况。然而，由于睡眠剥夺方案、任务范式、实验设计、受试者群体特征和成像技术存在很大差异，关于睡眠不足对参与任务的大脑的影响尚无共识。本荟萃分析的目的是确定在不同注意力任务中急性完全睡眠剥夺共同改变的大脑激活情况。
对实验性睡眠剥夺期间注意力任务表现的神经影像学研究进行基于坐标的荟萃分析。
使用当前版本的激活可能性估计（ALE）方法进行荟萃分析。作者检索了已发表的文章，确定了11项睡眠剥夺神经影像学研究，这些研究使用了不同的注意力任务，共有185名参与者，相当于81个用于ALE分析的焦点。
荟萃分析显示，与清醒状态相比，睡眠剥夺后多个区域的大脑激活显著降低，包括双侧顶内沟、双侧岛叶、右侧前额叶皮质、内侧前额叶皮质和右侧海马旁回。与清醒状态相比，睡眠剥夺后仅在双侧丘脑发现激活增加。
急性完全睡眠剥夺会降低额顶注意力网络（前额叶皮质和顶内沟）和突显网络（岛叶和内侧前额叶皮质）的大脑激活。睡眠剥夺后丘脑激活增加可能反映了睡眠丧失的去唤醒作用与任务表现对丘脑活动的唤醒作用之间的复杂相互作用。
