Takata M, Denton K M, Woods R L, Anderson W P
Emily E.E. Stewart Renal Laboratory, Baker Medical Research Institute, Melbourne, Australia.
Clin Exp Hypertens A. 1989;11(1):59-74. doi: 10.3109/10641968909035291.
Atrial natriuretic peptide (ANP, 2 micrograms/min) was infused intravenously into rabbits four weeks after renal wrap or sham operation. Mean arterial pressure (MAP) averaged 132 +/- 4 mmHg in the renal wrapped rabbits and 89 +/- 3 mmHg in the sham rabbits, and glomerular filtration rate (GFR) was significantly lower in the hypertensive rabbits (6.2 +/- 1.0 ml/min) than in sham rabbits (8.9 +/- 0.7 ml/min). In sham rabbits, ANP caused a significant diuresis, natriuresis and increase in GFR. Enalapril pretreatment blunted these responses. In the hypertensive rabbits, ANP reduced mean arterial pressure but did not cause significant diuresis or natriuresis or change in GFR. Enalapril pretreatment did not significantly alter this response to ANP. In separate experiments, nitroprusside was infused to lower arterial pressure in hypertensive rabbits by a similar amount to that achieved with ANP and this reduced GFR, sodium and urine excretion rates. Thus ANP maintained GFR and sodium excretion in hypertensive rabbits compared to an equihypotensive dose of nitroprusside. In summary, ANP did not cause natriuresis or diuresis in renal wrapped kidneys at a dose which was effective in normal kidneys, but did maintain GFR, sodium and water excretion rates, compared to an equally hypotensive dose of nitroprusside.
在对家兔进行肾包膜包裹手术或假手术四周后，静脉内输注心房利钠肽（ANP，2微克/分钟）。肾包膜包裹的家兔平均动脉压（MAP）为132±4毫米汞柱，假手术家兔为89±3毫米汞柱，高血压家兔的肾小球滤过率（GFR）（6.2±1.0毫升/分钟）显著低于假手术家兔（8.9±0.7毫升/分钟）。在假手术家兔中，ANP引起显著的利尿、利钠作用以及GFR增加。依那普利预处理减弱了这些反应。在高血压家兔中，ANP降低了平均动脉压，但未引起显著的利尿或利钠作用，也未使GFR发生改变。依那普利预处理并未显著改变对ANP的这种反应。在单独的实验中，向高血压家兔输注硝普钠以降低动脉压，降低幅度与ANP所达到的幅度相似，这降低了GFR、钠和尿排泄率。因此，与等降压剂量的硝普钠相比，ANP在高血压家兔中维持了GFR和钠排泄。总之，在对正常肾脏有效的剂量下，ANP在肾包膜包裹的肾脏中未引起利钠或利尿作用，但与等降压剂量的硝普钠相比，确实维持了GFR、钠和水的排泄率。
