Dardik B N, DiBello P M, Chatelain R E
Research Department, CIBA-GEIGY Corporation, Summit, NJ 07901.
Eur J Pharmacol. 1988 Dec 6;158(1-2):139-43. doi: 10.1016/0014-2999(88)90263-4.
A marked increase in the cyclic AMP content and concentration of the thoracic aorta was detected during the rise in blood pressure produced by one-kidney, one-clip and DOCA hypertension. This alteration was accompanied by the development of vascular hypertrophy and preceded the abnormal increase in DNA content observed in the arterial system during the more chronic stages of the disease. These experiments suggest the participation of cyclic AMP in the development of hypertension vascular growth.
在一侧肾、单夹和去氧皮质酮（DOCA）诱导的高血压所导致的血压升高过程中，检测到胸主动脉中环状单磷酸腺苷（cAMP）含量和浓度显著增加。这种改变伴随着血管肥大的发展，并且在疾病更慢性阶段动脉系统中观察到的DNA含量异常增加之前出现。这些实验表明cAMP参与了高血压血管生长的发展过程。
